IL-28B单核苷酸基因多态性与CHB干扰素疗效的相关性  

Correlation between IL-28B single nucleotide polymorphism and effectiveness of interferon in CHB

作　　者：丁慧俊[1] 

机构地区：[1]广东省东莞市人民医院感染内科,广东东莞523000

出　　处：《中国医药科学》2014年第17期9-11,共3页China Medicine And Pharmacy

基　　金：广东省东莞市科技计划项目(201110515001084)

摘　　要：目的探讨IL-28B单核苷酸基因多态性与慢性乙型肝炎(CHB)干扰素疗效的相关性。方法选取300例HBeAg阳性CHB患者,给予聚乙二醇化干扰素α(Peg-INF-α)规范治疗48周后以PCR法对IL-28B SNP rs12979860及IL-28B SNP rs8099917基因分型进行检测。结果治疗后HBV DNA定量、ALT、AST水平明显较治疗前下降(P<0.05),HBeAg转移率53.13%,随访1年后应答率49.44%;Peg-INF-α应答患者与非应答患者IL-28B SNP rs12979860基因型CC、CT、TT分布及等位基因C、T频率比较差异无统计学意义(P>0.05),IL-28B SNP rs8099917基因型TT、TG分布及等位基因T、G频率比较差异具有统计学意义(P<0.05)。结论 IL-28B SNP rs8099917可能对干扰素治疗的应答反应性形成影响,其中等位基因G的频率升高可能提示着干扰素的成功应答,因而检测IL-28B SNP rs8099917对干扰素治疗的CHB患者治疗疗效有一定预测价值。ObjectiveTo explore the correlation between IL-28B single nucleotide polymorphism and effectiveness of interferon in chronic hepatitis B （CHB）.Methods 300 cases of HBeAg positive patients with CHB were selected, and given pegylated interferon alpha （Peg-INF-a） standard treatment. The IL-28B SNP rs12979860 and IL-28B SNP rs8099917 genotyping were tested with PCR method after treatment of 48 weeks.Results HBV DNA quantification, ALT and AST levels after treatment decreased significantly compared with before treatment （P〈0.05）, HBeAg metastasis rate was 53.13%, response rate after a year of follow-up was 49.44%; the differences were no statistical significant in genotype CC, CT, TT distribution of IL-28B SNP rs12979860 and C, T frequency of allele between Peg-INF-a responder patients and non Peg-INF-a responder patients （P〉0.05）, the differences were statistical significant in genotype TT, TG distribution of IL-28B SNP rs8099917 and T, G frequency of allele （P〈0.05）. ConclusionIL-28B SNP rs8099917 may impact the formation of response to interferon treatment, including increased frequency of allele G could prompt the success of the interferon response, thus detecting IL-28B SNP rs8099917 to effectiveness of interferon treatment in CHB patients has certain predictive value.

关 键 词：IL-28B 单核苷酸基因多态性 慢性乙型肝炎 干扰素 

分 类 号：R512.62[医药卫生—内科学]