CD4^+CD25^+调节性T细胞可塑性分化的研究进展  

Research advance on plasticity of lineage differentiation of CD4^+CD25^+ regulatory T cells

作　　者：胡燕[1] 李永菊[1] 廖珍媛[1] 朱顺飞 熊思东[2] 徐林[1] 

机构地区：[1]遵义医学院免疫学教研室,563000 [2]苏州大学医学部基础医学与生物科学学院,215000

出　　处：《免疫学杂志》2014年第8期744-748,共5页Immunological Journal

基　　金：国家自然科学基金(81260398;31370918);贵州省国际合作项目(2010-7031);贵州省科技厅基金(C-491)

摘　　要：新近研究显示CD4+CD25+调节性T细胞的分化过程及其功能在一定条件下存在可塑性。这不仅体现了机体免疫调节机制的复杂性,而且还提示该过程与炎症、自身免疫性疾病和肿瘤等临床疾病的发生发展过程密切相关。本文就其相关研究进展做一综述。Recent researches revealed that under some conditions, the lineage differentiation and function of CD4＋CD25＋regulatory T cells（Tregs） are plastic. This phenomenon not only reflects the complexity of the immune regulatory mechanisms, but also indicates the close relationship between the flexibility of Tregs and the process of some clinical diseases, including inflammation, autoimmune diseases, cancers and so on. In this review, we briefly discuss the recent related progress.

关 键 词：CD4+CD25+调节性T细胞 分化 可塑性 

分 类 号：R392.12[医药卫生—免疫学]