细胞片层技术在口腔组织工程中的研究进展  

RESEARCH PROGRESS OF CELL SHEET TECHNOLOGY IN ORAL TISSUE ENGINEERING

作　　者：刘英[1] 王大庆[1] 莫金龙[1] 李宾中[1] 

机构地区：[1]川北医学院附属医院口腔科,四川南充637000

出　　处：《中国修复重建外科杂志》2014年第9期1168-1172,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81102063)~~

摘　　要：目的细胞片层技术(cell sheet technology,CST)克服了传统组织工程中的缺点,展示了在组织工程中的革新和优势。现就CST及其在口腔组织工程领域的研究进展进行综述。方法查阅近年来国内外关于CST以及在口腔组织工程中研究及应用的相关文献,进行分析、整理和总结。结果与传统组织工程技术相比,CST细胞接种率高、基质丰富、具有良好的生物相容性和理想操作性,有利于细胞移植成活和组织功能重建。CST在口腔牙周组织修复重建、口腔黏膜软组织缺损修复以及颌面部骨缺损修复中均有成功研究报道。结论 CST不断改进,并与传统组织工程技术相结合将会促进口腔组织工程学进一步发展。Objective Cell sheet technology （CST） demonstrates the innovation and advantage by overcoming some immanent shortcomings of traditional tissue engineering. To review the research progress of CST in oral tissue engineering. Methods The related home and abroad literature about CST and its application in stomatology was extensively reviewed and analyzed. Results Compared to the traditional tissue engineering technology, CST has the features of high seeding density, abundant matrix, good biological compatibility, and perfect operability, which can improve the survival rate of cell transplantation and promote functional reconstruction. It is reported that CST has been successfully used in the following fields, repair and reconstruction of periodontium, soft tissues of oral mucosa, and bones in maxillofacial region. Conclusion With the development of CST and combined with the traditional tissue engineering technologies, it will promote the tissue engineering further progress in stomatology.

关 键 词：细胞片层技术 口腔组织工程 研究进展 

分 类 号：R318.0[医药卫生—生物医学工程]