髓芯减压植骨及自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死疗效观察  

Effect of core decompression and bone grafting combined with autotransplantation of bone marrow mesenchymal stem cells for early stage of avascular necrosis of femoral head

作　　者：梁红锁[1] 黄克[1] 李林[1] 张波[1] 韦程寿[1] 

机构地区：[1]广西医科大学第三附属医院骨科,广西南宁530031

出　　处：《中国现代医药杂志》2014年第8期20-22,共3页Modern Medicine Journal of China

摘　　要：目的观察在髓芯减压植骨的基础上行自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死的临床疗效。方法采用髓芯减压植骨联合自体骨髓间充质干细胞移植治疗41例ARCO分期为Ⅰ、Ⅱ期的股骨头缺血性坏死患者,术后定期复查。结果所有患者经过11~29个月（平均15个月）的随访,除2例进展为ARCO分期Ⅲ期外,其余患者关节疼痛基本消失,活动范围接近或恢复正常,Harris评分由术前的（55.86±7.12）分提高到术后的（79.54±8.69）分,影像学检查结果显示股骨头囊性变消失,坏死区有新生骨小梁通过。结论髓芯减压植骨联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死,可改善髋关节活动功能,促进骨坏死修复,具有确切的临床疗效。Objective To study the effect of core decompression and bone grafting combined with autotransplantation of bone marrow mesenehymal stem cells for early stage of avaseular necrosis of femoral head. Methods 41 patients with avascular necrosis of femoral head in early stage were treated by core decompression and bone grafting combined with autotransplantation of bone marrow mesenehymal stem cells, followed-up regularly after operation. Results The average period of follow-up was 15 months （11-29 months）. Except two cases progressed to stage ARCO III, the joint pain of all patients disappeared,the movement range of the hip joint was normal or approximate to normal. The Harris score was （55.86±7.12） before operation and it increased significantly to （79.54±8.69） after operation. X-ray showed that cystic degeneration disappeared. The new bone trabeculae appeared in necrosis area. Conclusion Core decompression and bone grafting combined with autotransplantation of bone marrow mesenchymal stem cells treating for early stage of avascular necrosis of femoral head, can improve hip ruction, promote repair of osteonecrosis.h is an effective method for the treatment of femoral head necrosis.

关 键 词：股骨头坏死 髓芯减压 骨髓间充质干细胞 

分 类 号：R687.3[医药卫生—骨科学]