不同补肾法对骨质疏松症模型大鼠作用的比较研究  

Comparative Study of the Effects of Different Kidney-Nourishing Therapies on Rat Osteoporosis

作　　者：赵刚[1] 蔡定芳[1] 董淑范[2] 陈元新[3] 

机构地区：[1]复旦大学中西医结合研究所,上海200040 [2]辽宁中医学院附属医院,辽宁沈阳110032 [3]复旦大学附属华山医院,上海200040

出　　处：《上海中医药杂志》2002年第7期44-46,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：为探讨不同补肾法治疗骨质疏松症 (OP)的疗效 ,40只 3月龄Wistar大鼠分为A、B、C、D 4组 ,每组 10只 ,A组以生理盐水灌胃 ;其余 3组以 1 2 5 %维甲酸 2ml/d灌胃 ,在此基础上 ,C组另予温肾方 (主药 :淫羊藿、补骨脂、黄芪、熟地黄、菟丝子、鹿角胶、生龙骨、牡砺 )灌胃 ,D组予滋肾方 (主药 :熟地黄、山萸肉、山药、茯苓、枸杞子、龟板胶、生龙骨、牡砺 )灌胃 ,6周后比较 4组大鼠的变化。结果 :两补肾方对维甲酸大鼠血浆ALP和尿Ca/Cr、Hop/Cr的异常有不同程度的调整作用 ,其中D组优于C组 ;C组股骨BMC和腰椎BMD明显增加 ,D组股骨、腰椎BMD、BMC均明显增加 (P <0 0 1～ 0 0 5 )。提示 :滋补肾阴法对骨质疏松症模型大鼠的作用优于温补肾阳法。To observe the effects of different kidney-nourishing therapies on osteoporosis(OP),40 Wistar rats were equally randomized into four groups.Group A was given stomach perfusion of normal saline;the other three groups were given 1.25% vitamin A acid by stomach perfusion,2ml per day;in addition,group C was given 'Kidney-Warming Decoction' and group D was given 'Kidney-Nourishing Decoction' by stomach perfusion;after 6-week management,the four groups were compared.Results:In groups C and D,the plasma ALP and urine Ca/Cr,Hop/Cr were corrected to different degrees,better in group D than in group C;femoral BMC and lumbar BMD increased obviously in group C;both femoral and lumbar BMD and BMC increased significantly in group D(P<0 01～0 05).It is proved that kidney-nourishing therapy has better effects on OP than kidney-warming therapy does.

关 键 词：骨质疏松症 温补肾阳法 滋补肾阴法 对比分析 OP 

分 类 号：R259.8[医药卫生—中西医结合]