ON、PINP、OPG、IGF-1、TGF-β与股骨颈BMD相关性研究  

Correlation study between ON,PINP,OPG,IGF-1,TGF-β and BMD of the femoral neck

作　　者：张萌萌[1] 毛未贤[1] 高远[1] 马倩倩[1] 

机构地区：[1]吉林省骨质疏松诊疗中心(吉林大学第四医院),长春130011

出　　处：《中国骨质疏松杂志》2014年第8期880-884,912,共6页Chinese Journal of Osteoporosis

摘　　要：目的研究骨粘连蛋白(ON)、Ⅰ型原胶原N-端前肽(PINP)、骨保护素(OPG)、胰岛素样生长因子1(IGF-1)、转化生长因子β(TGF-β)与股骨颈骨密度(BMD)的相关性。方法采用美国Hologic公司Discovery WA型骨密度仪检测股骨颈BMD,采用美国Thermo公司全自动酶标免疫分析仪检测ON、PINP、OPG、IGF-1、TGF-β。将913例受试者检测结果按10岁为年龄段分组,应用SPSS 13.0分析软件进行统计分析。结果男性与女性正常组血清ON、PINP、IGF-1、TGF-β水平均明显高于骨质疏松组,而正常组血清OPG水平均明显低于骨质疏松组(P<0.05)。女性血清ON、PINP、IGF-1、TGF-β水平与股骨颈BMD呈正相关(P<0.05),OPG水平与股骨颈BMD呈负相关(P<0.05)。男性血清ON、IGF-1、TGF-β水平与股骨颈BMD呈正相关(P<0.05),OPG水平与股骨颈BMD呈负相关(P<0.05)。结论血清ON、PINP、IGF-1、TGF-β水平与股骨颈BMD正相关,血清OPG水平与股骨颈BMD负相关。ON、PINP、OPG、IGF-1、TGF-β在骨代谢过程中相互作用影响骨质量,与股骨颈BMD存在重要关联。Objective To investigate the correlation between osteonectin（ ON）,type Ⅰ procollagen amino-terminal peptide（ PINP）,osteoprotegerin（ OPG）,insulin growth factor 1（ IGF-1）,transforming growth factor β（ TGF-β）,and the bone mineral density（ BMD） of the femoral neck. Methods BMD of the femoral neck was detected using the bone mineral density detector（ Hologic Discovery-WA,USA）. The serum levels of ON,PINP,OPG,IGF-1,and TGF-β were detected using automatic enzyme immunoassay analyzer（ Thermo,USA）. All the 913 subjects were divided into different groups according to a 10-year range. All the data were analyzed using a SPSS 13. 0 software. Results The serum levels of ON,PINP,IGF-1,and TGF-β in male and female subjects in normal group were significantly higher than those in osteoporosis group,while the serum level of OPG in normal group was significantly lower than that in osteoporosis group（ P 〈 0. 05）. The serum levels of ON,PINP,IGF-1,and TGF-β in females were positively correlated with BMD of the femoral neck（ P 〈 0. 05）,while the OPG level was negatively correlated with BMD of the femoral neck（ P 〈 0. 05）. The serum levels of ON,IGF-1,and TGF-β in males were positively correlated with BMD of the femoral neck（ P 〈 0. 05）,while the OPG level was negatively correlated with BMD of the femoral neck（ P 〈 0. 05）.Conclusion The serum levels of ON,PINP,IGF-1,and TGF-β are positively correlated with BMD of the femoral neck,but the OPG level was negatively correlated with BMD of the femoral neck. In the process of bone metabolism,ON,PINP,OPG,IGF-1,and TGF-β can affect bone mass through their interaction. They have a significant association with BMD of the femoral neck.

关 键 词：骨粘连蛋白(ON) Ⅰ型原胶原N-端前肽(PINP) 骨保护素(OPG) 胰岛素样生长因子(IGF-1) 转化生长因子β(TGF-β) 股骨颈骨密度(BMD of the femoral neck) 

分 类 号：R34[医药卫生—基础医学]