合并糖尿病的急性冠脉综合征患者血清白细胞介素-6、基质金属蛋白酶-9与颈动脉斑块稳定性的关系  

Study on the correlation between serum interleukin-6, matrix metalloproteinase-9 and stability of carotid artery plaque in patients of acute coronary syndrome complicated with diabetes mellitus

作　　者：阳运强 钟文[1] 廖强[1] 赵强[1] 孙静[1] 

机构地区：[1]四川省彭州市人民医院心内科, 611930

出　　处：《中华实验外科杂志》2014年第9期2046-2048,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨合并糖尿病的急性冠脉综合征（ACS）患者血清白细胞介素-6（IL-6）、基质金属蛋白酶-9（MMP-9）与颈动脉斑块稳定性的关系.方法 随机选择合并糖尿病的ACS患者104例,对双侧颈动脉行B超检查,分成4组：内膜-中层厚度（IMT）正常组（20例）、IMT增厚组（36例）,稳定斑块组（30例）及不稳定斑块组（18例）,另选取同期单纯糖尿病患者（40例）作为对照组;采用酶联免疫吸附试验法（ELISA）测定患者血清IL-6、MMP-9水平.结果 IMT正常组、IMT增厚组、稳定斑块组及不稳定斑块组患者血清IL-6、MMP-9水平均明显高于对照组[（295.3±43.8）、（369.5±46.2） 、（446.2±44.7）、（533.6 ±48.1）ng/L比（216.7 ±39.8） ng/L和（172.3 ±24.6）、（228.6±26.2）、（287.4±30.1）、（372.8±31.5） μg/L比（98.7±20.7）μg/L],差异有统计学意义（P＜0.05）,且在IMT正常组、IMT增厚组、稳定斑块组及不稳定斑块组中,血清IL-6和MMP-9水平逐渐升高,各组间的差异均有统计学意义（P＜0.05）.结论 合并糖尿病的ACS患者血清IL-6、MMP-9水平与颈动脉斑块稳定性明显相关,可提示ACS患者血管病变的发生发展.Objective To investigate the correlation between serum interleukin-6,matrix metallo-proteinase-9 and stability of carotid artery plaque in patients of acute coronary syndrome （ACS） complicated with diabetes mellitus （DM）.Methods 104 cases of ACS complicated with DM were selected,then according to the results of the ultrasound measurement of bilateral carotid artery,they were divided into intima-media thickness （IMT） normal group （20 cases）,IMT thickening group （36 cases）,stable plaque group （30 cases）,and unstable plaque group （18 cases）.Serum levels of interleukin （IL）-6,matrix metalloproteinase （MMP）-9 were measured by enzyme linked immunosorbent assay （ELISA）.Results The levels of plasma IL-6 and MMP-9 in IMT normal group,IMT thickening group,stable plaque group and unstable plaque group were higher than those in control group [（295.3 ± 43.8）,（369.5 ± 46.2）,（446.2±44.7）,（533.6 ±48.1） ng/L vs.（216.7 ±39.8） ng/L and （172.3 ±24.6）,（228.6 ±26.2）,（287.4±30.1）,（372.8 ±31.5） μg/L vs.（98.7 ±20.7） μg/L],and there were significant differences （P 〈 0.05 for all） ; In IMT normal group,IMT thickening group,stable plaque group and unstable plaque group,the levels of plasma IL-6 and MMP-9 gradually increased,and the differences among the groups were statistically significant （P 〈 0.05 for all）.Conclusion There is a significant correlation between serum IL-6,MMP-9 levels and carotid plaque stability in patients of ACS complicated with diabetes mellitus,which can provide some indicative effect for the occurrence and development of vascular disease.

关 键 词：急性冠脉综合征 糖尿病 白细胞介素-6 基质金属蛋白酶-9 颈动脉斑块 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]