桑蒂复肝胶囊对D-半乳糖胺致小鼠急性肝损伤的保护作用  

Protection of Sangdi Fugan Capsule on Mice with D-GlaN-induced Acute Liver Injury

作　　者：李莉[1] 张喜德[2] 张恩户[2] 

机构地区：[1]河南省平顶山学院医学院,平顶山467000 [2]陕西中医学院,咸阳712046

出　　处：《河北中医药学报》2014年第3期9-11,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：陕西省科技厅课题基金资助项目:No 03K10-G14

摘　　要：目的:研究桑蒂复肝胶囊对D-半乳糖胺(D-GlaN)致小鼠急性肝损伤的保护作用。方法:采用腹腔注射D-GlaN建立小鼠急性肝损伤模型,观察桑蒂复肝胶囊对小鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平,肝组织匀浆超氧化物歧化酶(SOD)活力、脂质过氧化物丙二醛(MDA)含量和肝组织病理学检查的影响。结果:与模型组对比,桑蒂复肝胶囊高、中剂量组能够显著降低小鼠血清ALT、AST水平,提高肝组织匀浆SOD活力,降低MDA含量,改善肝组织病理损伤程度(P<0.05或P<0.01)。结论:桑蒂复肝胶囊对D-GlaN致小鼠急性肝损伤有明显的保护作用。Objective：to explore the protective effect of Sangdi Fugan Capsule on the mice with D-GlaN-induced acute liver injury.Methods：Mice models with acute liver injury were made by intraperitoneal injection of D -GlaN.Observe the effect of the capsule on ALT, AST in serum, SOD activity in liver sissue homogenate , MDA content and liver histopathology.Results：Compared to model group, Sangdi Fugan Capsule of high and low dosage groups could significantly decrease ALT and AST content , increase SOD activity, decrease MDA content, improve the injury of liver tissue （ P 〈0.05 or P 〈0.01） .Conclusion：Sangdi Fugan Capsule hasan apparent protective effect on the mice with D-GlaN-induced acute liver injury.

关 键 词：桑蒂复肝胶囊 D-半乳糖胺 肝损伤 保护作用 肝炎 乙肝解毒胶囊 

分 类 号：R285.5[医药卫生—中药学]