一份全肠外营养液的稳定性影响考察  

Stability Assay of a Total Parenteral Nutrition Preparation

作　　者：高哲[1] 赵青威[1] 杨志海[1] 胡燕[1] 张相宜[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《药品评价》2014年第12期28-31,共4页Drug Evaluation

基　　金："蒲黄总黄酮对肾小球系膜细胞增殖的影响及机制研究";浙江省药学会医院药学专项科研基金项目;编号2012ZYY01;"FMEA在门诊药房青年文明号调剂质量持续提高中的应用研究";浙江大学附属第一医院共青团工作研究课题项目

摘　　要：目的：考察我院一份全肠外营养液处方在不同配制顺序下溶液pH值变化，以及一价电解质浓度对该TPN液稳定性的影响，为今后同类TPN的稳定性提供参考。方法：6组全肠外营养液分别加入不同复方氨基酸注射液和不同浓度一价电解质（Na＋浓度），于各步骤混合后0h及20℃--22℃下贮存12、24h后分别取样测定pH值，并肉眼观察其外观变化。结果：不同配制顺序下该全肠外营养液的pH值在24h内稳定，同样处方比例下加入复方氨基酸注射液（18AA-III）的出现分层现象，加入复方氨基酸注射液（18AA-II）的未发生明显变化；加入Na＋终浓度100、150、200、250mmol/L的TPN液24h后均未出现分层析出现象。结论：该份全肠外营养液处方在不同配制顺序下溶液pH值无变化，一价电解质250mmol/L对该处方的24h稳定性无影响，不同复方氨基酸注射液的选择对全肠外营养液稳定性有影响。Objective：To investigate the pH value and monovalent electrolyte concentration in different preparation order and its impact on the stability of a total parenteral nutrient formulation and to provide a reference for the future stability of similar TPN preparation. Method：6 groups of total parenteral nutrients were injected by different compound amino acid injections and different concentrations of monovalent electrolyte concentration （Na＋）. 0 h, 12 h, 24h after each mixing step under 20℃～22℃storage, samplings were drawed to determine the pH value, and the changes in appearance were observed. Results：The pH value under different preparation order was stable within 24 h. Stratified phenomenon appeared when compound amino acid injection （18AA-III） was added to the nutrient solution while the solution did not change significantly when compound amino acid injection （18AA-II） was added under the same prescription proportion;TPN with Na＋concentration at 100, 150, 200 and 250 mmol/L showed no stratified phenomenon 24h after preparation. Conclusion： pH value of the TPN under different preparation order was stable. Monovalent electrolyte up to 250 mmol/L had no effect on 24h stability of this prescription. Different compound amino acid injection had effects on the stability of total parenteral nutrition solution.

关 键 词：全肠外营养液 PH值 电解质 稳定性 

分 类 号：R927.11[医药卫生—药学]