头孢西丁钠的合成进展  

Development in Synthesis of Cefoxitin Sodium

作　　者：尹伟成 彭东明[1] 周汨[1] 王福东[1] 杜鹏[1] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208

出　　处：《精细化工中间体》2014年第4期17-22,共6页Fine Chemical Intermediates

基　　金：湖南省自然科学基金项目(13JJ3099);湖南省科技计划项目(2012SK3134)

摘　　要：头孢西丁钠是一种具有长效、广谱抗菌特点的第二代头孢类抗生素,因其对β-内酰胺酶的耐药性强而得到广泛使用,具有很好的市场发展前景。综述了头孢西丁钠的各种合成方法,并评价了其优缺点。Cefoxitin, the second-generation cephalosporins antibiotics, is permanence and have a broad spectrum of antibacterial activity. Because of its stong resistance to β-lactamase, it was widely used and has a good market prospects. In this paper synthesis methods for cefoxitin sodium were reviewed and their advantages and disadvantages were described.

关 键 词：头孢西丁钠 头孢菌素 抗生素 药物合成 

分 类 号：TQ453.299[化学工程—农药化工]