肝细胞生长因子逆转心肌肥厚作用的研究进展  

Research progress of hepatocyte growth factor reverse myocardial hypertrophy function

作　　者：董丽萍[1] 蒋园[1] 曾凯[1] 耿帅[1] 佘砚云 龚冬梅[1] 

机构地区：[1]哈尔滨医科大学药理教研室,哈尔滨150081

出　　处：《中国临床药理学杂志》2014年第9期868-870,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金项目资助(81202523);黑龙江省高校战略后备人才出国研修基金资助项目

摘　　要：心肌肥厚是许多心脏疾病共有的病理表现,严重将导致心力衰竭。肝细胞生长因子(HGF)是多功能的细胞因子,近些年研究表明HGF在防治心血管疾病中有重要作用。本文着眼于HGF在心血管系统中发挥作用的分子机制和信号通路,总结现有的关于HGF与心肌肥厚的相关研究,分析HGF对治疗心肌肥大的潜在作用或可能的不利影响。Cardiac hypertrophy is a common phenomenon in heart diseases,ultimately lead to heart failure. Hepatocyte growth factor（ HGF）,which is a pleiotropic cytokine. It has been considered as a promising candidate for cardiovascular therapy for several years. This review focus on these molecular mechanisms and signaling pathways of HGF targeted in cardiovascular system,and summarizes current research about HGF on cardiac hypertrophy,analyses the potential contribution or adverse effect of HGF on cardiac hypertrophy turns out in different heart diseases.

关 键 词：心肌肥厚 肝细胞生长因子 抗凋亡 抗纤维化 

分 类 号：R541[医药卫生—心血管疾病] R972[医药卫生—内科学]