PDDA/MWNT自组装膜修饰碳纤维微电极选择性测定多巴胺的研究  

Study on PDDA/MWNT self-assembled monolayer modified carbon fiber microelectrodes for selective detection of dopamine

作　　者：赵灵芝[1] 张小清[1] 苗延青[1] 邓文婷[1] 胡颢[1] 

机构地区：[1]西安医学院药学院,西安710021

出　　处：《化工新型材料》2014年第9期122-124,128,共4页New Chemical Materials

基　　金：国家自然科学基金(21305109;81202492;81302706);陕西省科学技术厅自然科学基础研究计划项目(2014JQ2073;2014K02-11-01);西安医学院博士启动基金(2012Doc 09)

摘　　要：结合了碳纳米管和微电极两者的优越性,通过静电自组装方法有序地将混酸切割多壁碳纳米管修饰到碳纤维微电极上,并表征了自组装膜PDDA/MWNT修饰到碳纤维微电极上的均匀程度和稳定性,进一步采用循环伏安法研究了多巴胺和抗坏血酸在该修饰电极上的电化学行为。结果表明,该修饰微电极成功实现在抗坏血酸共存下选择性测定多巴胺,峰电流与多巴胺浓度在4μM/L到52μM/L之间呈现良好的线性关系,最低检测限是0.1μmol/L,该工作为多巴胺的活体、实时的电化学选择性测定奠定了基础。A new electrochemical method to integrate both virtues of carbon nanotubes （CNTs） and microelectrodes was demonstrated. By use of self-assembly method based on electrostatic interaction, multi-walled carbon nanotubes （MWNTs） treated and shortened in 1：3 concentrated nitric-sulfuric acid was attempted to assembly onto carbon fiber mi- croelectrodes. Furthermore,the stability and homogeneity of the assembled PDDA/MWNT monolayer were characterized and the electrocatalysis effect of PDDA/MWNT for the oxidation of dopamine and ascorbate was demonstrated. The results indicated that the as-assemled microelectrode can selectively detect dopamine with the coexistence of ascorbate,which estab-lished the foundation for in vivo, real-time, selective determination of dopamine.

关 键 词：碳纤维微电极 多壁碳纳米管 抗坏血酸 多巴胺 

分 类 号：O613.71[理学—无机化学] O646.54[理学—化学]