选择性雄激素受体调节剂（Sarm）对迟发性腺功能减退大鼠的作用研究  

The effect of selective androgen receptor modulator （Sarm） on aged male rats of late-onset hypogonadism

作　　者：卞少华[1] 刘春[1] 

机构地区：[1]太原山西医科大学第一医院,山西030001

出　　处：《国际泌尿系统杂志》2014年第5期646-650,共5页International Journal of Urology and Nephrology

摘　　要：目的 通过观察选择性雄激素受体调节剂对迟发性腺功能减退大鼠的作用,为治疗LOH提供理论依据.方法 将30只符合标准的老年Wistar大鼠作为LOH动物模型,并随机分成3组：对照组（A）、DHT组（B）、Sarm组（C）,分别给予空白溶剂、雄激素及选择性雄激素受体调节剂（Sarm）进行干预,实验4周后观察各组大鼠LOH症状的改善情况并评分,检测血清游离睾酮的水平,计算前列腺相关指数.结果 干预4周后A、B、C三组大鼠LOH症状评分分别为（18.20±1.87）、（30.00±2.49）、（35.20±1.87）,血清游离睾酮分别为（2.248±0.305）、（1.088±0.258）、（2.526±0.283） pg/mL,前列腺指数分别为（0.321±0.008）％、（0.419±o.015）％、（0.304±0.007）％,各组间差异有统计学意义（P＜0.01）.结论 Sarm可能通过其与雄激素受体高度亲和力及选择性调节雄激素受体表达,明显改善LOH模型大鼠的LOH症状,有效抑制前列腺组织的增生,不影响自身睾酮的分泌.Objectives To investigate the large effective ways and means for aged male rats of late-onset hypogonadism by selectively modulate androgen receptor.Methods A total of 30 aged male rats were selected as LOH model and randomly divided into 3 groups：control group（A）,DHTgroup（B）,Sarm group（C）.Each group were treated with subcutaneous injection of blank solvent,dihydrotestostemne （DHT）and Sarm during the next 4 weeks.After 4 weeks,we observed and scored the LOH symptoms of every rats,detect the levels of serum free testosterone,and calculate the prostatic index.Results The scores of LOH symptom were 18.20 ± 1.87,30.00 ± 2.49,35.20 ± 1.87,and serum free testosterone were 2.248 ± 0.305,1.088 ± 0.258,2.526 ± 0.283pg/mL,and prostate index were 0.321 ± 0.008,0.419 ± 0.015,0.304 ± 0.007％,the difference between every two groups was statistically significant（P ＜ 0.01）.Conclusions By its high affinity and selectivity to adjust androgen receptor expression,Sarm can obviously improve the symptoms of LOH model rat and restrain the hyperplasia of prostate tissue,however,it does not affect the secretion of testosterone.

关 键 词：性腺功能减退症 受体 雄激素 睾酮 大鼠 

分 类 号：R588[医药卫生—内分泌]