依帕司他治疗糖尿病感觉神经病变的临床疗效观察  

The therapeutic effect of diabetic sensory neuropathy treated with epalrestat

作　　者：汤云昭[1] 倪长霖[1] 汪玮琳[1] 靳建明[1] 尹爱莉[1] 刘晨淼 徐津咏[1] 潘从清[1] 孟东[1] 

机构地区：[1]天津医科大学代谢病医院卫生和计划生育委员会激素与发育重点实验室,天津300070

出　　处：《中国现代医生》2014年第26期55-57,共3页China Modern Doctor

摘　　要：目的观察依帕司他治疗糖尿病感觉神经病变的临床疗效。方法选择2型糖尿病周围神经病变患者34例。测定治疗前后腓总神经及胫总神经传导速度。结果 61%的受试者治疗前腓总神经感觉神经传导速度减慢,治疗后32%的受试者该神经传导速度减慢;97%的受试者治疗前胫总神经感觉神经段1传导速度减慢,治疗后65%的受试者该神经传导速度减慢;腓总神经感觉神经治疗后其神经传导速度较治疗前明显增快,胫总神经感觉神经运动节段1在治疗后其神经传导速度较治疗前明显增快。结论口服依帕司他是治疗糖尿病周围神经病变的有效手段之一。Objective This study observed the clinical curative effects of aldose reductase inhibitor epalrestat in treat- ment of diabetic sensory neuropathy. Methods Thirty-four diabetic sensory neuropathy patients were selected. The nerve electrophysiological data were collected before and after treating with epalrestat. Results The ratios of nerve con- ductive velocity in peroneal nerve sensory showed slowing down than normal before and after the treatment, which were respectively 61% and 32%; The ratios of the nerve conductive velocity in tibial nerve sensory nerve segment 1 showed slowing down before and after the treatment,which were respectively 97% and 65%; The nerve conductive velocity of the peroneal sensory nerve after treatment was significantly faster than that before treatment, the nerve conductive ve- locity of the the tibial nerve sensory nerve motion segments in 1 after treatment was significantly faster than that before treatment. Conclusion Epalrestat is one of the effective methods in the treatment of diabetic peripheral neuropathy.

关 键 词：糖尿病 周围神经病变 依帕司他 神经传导 

分 类 号：R587.2[医药卫生—内分泌]