人肠道菌对天然产物代谢及转化的研究进展  

Advances in study on metabolism and biotransformation of natural products by human intestinal bacteria

作　　者：赵磊[1] 陈剑[1] 任冰如[1] 李维林[1] 

机构地区：[1]江苏省中国科学院植物研究所江苏省抗糖尿病药物筛选服务中心,江苏南京210014

出　　处：《微生物学通报》2014年第9期1872-1881,共10页Microbiology China

基　　金：国家自然科学基金青年基金项目(No.21102058);江苏省科技基础设施建设计划-科技公共服务平台项目(No.BM2011117);江苏省自然科学基金项目(No.BK20141387)

摘　　要：天然产物的人肠道菌代谢及转化研究已引起各国学者的重视,并作为热点课题进行了大量研究工作。本文对近二十年来各国学者关于黄酮类、萜类、苯丙素类、生物碱类、甾体类及其他天然产物的人肠道菌代谢及转化研究工作进行了综述,总结了各类天然产物在人肠道菌作用下的代谢路径及转化规律,以期为该领域的进一步深入研究提供参考。The study on metabolism and biotransformation of natural products by human intestinal bacteria is receiving more and more attention. To gain insight and to trigger additional research in this field, we provide in this an overview of selected natural products bio-transformed or metabolized by human intestinal bacteria through the reported literatures in recent 20 years. The mechanism as well as pathway of metabolism or bio-transformation by human intestinal bacteria was discussed,according to the categories of natural products such as flavonoids, terpenoids, phenylpropanoids,alkaloids, steroids and the others. We also address the needs in further studies on metabolism and conversion action of natural products by human intestinal bacteria.

关 键 词：人肠道菌 天然产物 代谢 转化 

分 类 号：R378[医药卫生—病原生物学]