多枝罗丹明酰肼类荧光探针的研究进展与应用  

Progress and Applications of Multi-branched Rhodamine Hydrazone Fluorescent Sensors

作　　者：杨杨[1] 高超颖[1] 许良[1] 段莉梅[1] 李斌[2] 

机构地区：[1]内蒙古民族大学化学化工学院,通辽028000 [2]中国科学院长春光学精密机械与物理研究所,长春130033

出　　处：《应用化学》2014年第10期1123-1134,共12页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金项目(81260682);内蒙古自然科学基金博士基金(2014BS0205);内蒙古民族大学博士科研启动基金(BS311)资助项目~~

摘　　要：罗丹明以其良好的光稳定性、光物理性质和荧光效应得到了人们的极大重视。基于罗丹明的螺环衍生物与被检测物质作用开环而产生荧光响应的特性,将两个或多个罗丹明母体单元构筑到包含特异性的识别单元的探针分子中,形成多枝的罗丹明酰肼类荧光探针,不仅可以弥补单分子探针的某些功能缺陷,而且可以使其具有更高灵敏度、更高选择性和可靠性,更加有利于分析检测。本文着重从设计原理、识别性能、应用范围等方面介绍了多枝罗丹明探针在Hg2+、Cu2+、Fe3+和Al3+等离子检测中发展趋势,并展望了这类荧光探针在活细胞金属离子光学成像的应用前景。Due to their excellent photostability and photophysical properties, the rhodamine fluorochrome has attracted considerable interest from chemists. Spiroeyelic derivatives of rhodamine dyes are useful sensing platforms since the ring-opening process leads to a turn-on fluorescence change. A multi-branched rhodamine derivative with an appropriate ligand on spirolactam ring that is capable of binding a single metal ion is expected to display enhanced absorbance as well as fluorescence properties required for trace metal analysis. This review provides an insight to the design and fabrication of the multi-branched rhodamine sensing system for metal-ions applications. The perspective for luther research of rhodamine-based cell imaging optical sensors are also discussed.

关 键 词：多枝罗丹明 荧光探针 荧光识别 检测限 细胞成像 

分 类 号：O626[理学—有机化学] O641[理学—化学]