中医药与癌化学预防研究现状与展望  

The research status and prospect of cancer chemoprevention by Chinese medical materials

作　　者：邹剑铭 张英[2] 

机构地区：[1]解放军兰州军区临潼疗养院第二疗养区,西安710600 [2]中国中医科学院广安门医院.北京100053

出　　处：《中国新药杂志》2014年第18期2150-2154,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81102718,81273947);国际科技合作与交流专项(2013DFA32540)

摘　　要：中医"治未病"集中体现于"未病先防",与现代医学所说的癌化学预防概念非常相似。因为中医治疗疾病所用的中药大多数为药食同源,少或者无不良反应,符合癌化学预防过程长期而持续的临床特点;而且,中药及其复方在癌化学预防中具有独特的优势,那就是由于其成分多样,变化多端,所以其作用是多靶点、多途径的综合作用,符合癌症发生机制的多因性和复杂性的特色,因此,在中药材的宝库中筛选癌化学预防药物,是实现癌化学预防的有效途径。本文综述了近年来在中医药癌化学预防方面研究工作,总结成绩,发现问题,并提出可能的解决途径。相信只要一方面建立中药标准癌化学预防研究系列技术,同时加快转化研究,中医药在开发"癌化学预防"药物方面必将提供一定的帮助。The theory of ＂Preventive Treatment of Disease＂ is the core theory of traditional Chinese medicine （TCM） , which is in agreement with the cancer chemoprevention in modern medicine. The major advantages of applying Chinese herbs as agents to prevent cancers are as following： Firstly, almost all the Chinese herbs are homology of foods, so they have no or little side effects and toxicities. This is beneficial for the long-term prevention of cancers. Secondly, the compositions of TCM herbs are muhiple, so the mechanisms of the actions involve muhitargets and multi-pathway. This is in accord with the multi-factors and complicated mechanisms of cancer occurrence. So screening effective cancer chemoprevention agents in Chinese medicinal materials is a great way to realize the cancer prevention. In this paper, we summarized the research on cancer chemoprevention in recent years, hoping to offer references for future work.

关 键 词：癌化学预防 中药 综述 

分 类 号：R979.1[医药卫生—药品]