IL-6基因多态性与COPD发病风险关系的Meta分析  

Association between IL-6 Gene Polymorphism and the Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis

作　　者：魏江涛[1] 候明勇[1] 何斌[1] 邓磊[1] 廖玍[2] 

机构地区：[1]成都大学附属医院麻醉科,成都610081 [2]四川大学华西口腔医院口腔疾病研究国家重点实验室,成都610041

出　　处：《中国循证医学杂志》2014年第9期1131-1134,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价白细胞介素6(IL-6)基因-174G/C多态性与慢性阻塞性肺疾病(COPD)发病风险的相关性。方法计算机检索PubMed、EMbase、CNKI、WanFang Data、CBM和VIP数据库有关IL-6基因-174G/C多态性与COPD发病风险的病例-对照研究,检索时限均为从建库至2013年6月。由2位研究者按纳入与排除标准独立筛选文献、提取资料后,采用RevMan 5.2软件进行Meta分析。结果最终纳入5个研究,共计487例COPD患者和786例对照。Meta分析结果显示IL-6基因-174G/C多态性和COPD发病风险无相关性:GC+CC vs.GG:OR=1.01,95%CI(0.76,1.34),P=0.95;CC vs.GC+GG:OR=1.04,95%CI(0.70,1.54),P=0.85;CC vs.GG:OR=1.05,95%CI(0.69,1.61),P=0.81;GC vs.GG:OR=1.00,95%CI(0.74,1.35),P=0.99;C vs.G:OR=1.02,95%CI(0.83,1.24),P=0.88。结论 IL-6基因-174G/C多态性可能不是COPD发病风险的危险因素。Objective To systematically review the association between -174G/C polymorphism in interleukin-6 （IL-6） gene and the risk of chronic obstructive pulmonary disease （COPD）. Methods We electronically searched Pub- Med, EMbase, CBM, WanFang Data, CNKI and VIP for case-control studies on the correlation between IL-6 gene -174G/ C polymorphism and the risk of COPD. Two reviewers independently screened the studies according to the inclusion and exclusion criteria and extracted data. 1-hen meta-analysis was conducted using RevMan 5.2 software. Results A total of 5 studies involving 487 COPD cases and 786 controls were included. The results of meta-analysis showed that, there was no significant association between IL-6 gene SNP-174G/C and risks of COPD： GC＋CC vs. GG： OR=I.01, 95%CI 0.76 to 1.34, P=0.95; CC vs. GC＋GG： OR=1.04, 95%CI 0.70 to 1.54, P=0.85： CC vs. GG： OR=l.05, 95%CI 0.69 to 1.61, P=0.81; GC vs. GG： OR=I.00, 95%CI 0.74 to 1.35, P=0.99; C vs. G： OR=l.02, 95%CI 0.83 to 1.24, P=0.88. Conclusion IL-6 -174G/C gene polymorphism may not be a risk factor that causes COPD.

关 键 词：慢性阻塞性肺疾病 IL-6 多态性 META分析 病例一对照研究 

分 类 号：R563.9[医药卫生—呼吸系统]