应用超声射频信号技术软件评估高甘油三脂患者颈动脉结构和功能的早期改变  

Evaluation of early alterations of common carotid artery structure and function in patients with hypertriglyceridemia using ultrasound radio-frequency analyzing technique

作　　者：张军[1] 赵新民[2] 周艳华[1] 周磊[1] 师林[1] 

机构地区：[1]天津市南开区王顶堤医院超声科,300191 [2]天津市第三中心医院超声科,300170

出　　处：《国际生物医学工程杂志》2014年第4期227-229,250,I0004,共5页International Journal of Biomedical Engineering

摘　　要：目的 应用超声射频信号技术评价高甘油三脂血症（HTG）患者颈动脉内中膜厚度及弹性功能早期改变的临床意义.方法 将48例HTG患者（甘油三脂≥1.8 mmol/L）作为受试组,应用超声射频信号血管内中膜厚度定量分析（QIMT）及动脉僵硬度定量分析（QAS）技术,观察颈动脉内中膜厚度（IMT）及弹性指标的改变,包括颈动脉内径（D）、管壁扩张系数（DC）、顺应系数（CC）、弹性系数（α）、弹性系数（β）及脉搏波传播速度（PWV）;并将50例健康人作为对照组.分析上述参数在2组间的差别及弹性指标之间的相关性.结果 HTC组的2侧颈动脉IMT、α、β及PWV的弹性指标均高于对照组,DC、CC较对照组降低,其差异有统计学意义（P＜0.05）.组内2侧颈动脉弹性指标之间存在差异,CCL＞CCR,αL＞αR,βL＞βR,PWVL＞PWVR.CC与α、β、PWV呈负相关（P＜0.05）,α、β、PWV之间呈正相关（P＜0.05）.2组颈动脉内径（D）比较差异无统计学意义（P＞0.05）.结论 动脉弹性异常早于形态学的改变,应用超声射频信号技术能提供HTG患者早期颈总动脉结构和弹性功能改变的信息,对其临床早期诊疗具有一定意义.Objective To evaluate the clinical value of early alterations of carotid arterial intima-media thickness （IMT） and elastic function in patients with hypertriglyceridemia （HTG） using ultrasound radio-frequency technique.Methods 48 patients （triglyceride value ≥ 1.8 mmol/L） were chosen as HTG group.Quantitative intimamedia thickness （QIMT） and quantitative arterial stiffness （QAS） techniques were used to observe the alterations of carotid arterial IMT and elastic index,including diameter of carotid artery （D）,distensibility coefficient （DC）,compliance coefficient （CC）,elasticity coefficient （α）,elasticity coefficient （β） and pulse wave velocity （PWV）.50 healthy subjects were recruited in control group.Differences of the above-mentioned parameters were analyzed,as well as the elastic index connections between the two groups.Results IMT,α,β,and PWV index of bilateral carotid arteries in HTG group was higher than that of the control group,while the DC and CC index was lower,and the differences was statistically significant （P＜0.05）.Within the groups there were differences between the elastic indexes of bilateral carotid arteries.In control group and the HTG group：CCL＞CCR,αL＞αR,βL＞βR,PWVL＞PWVR.CC was negatively correlated to α,β and PWV （P＜0.05）.Meanwhile,there was positive correlation among α,β and PWV （P＜0.05）.The differences of D between two groups had no statistical significance （P＞0.05）.Conclusions The abnormity of arterial occurs earlier than the morphological change,while the ultrasound radio-frequency technique can provide information of earlier alteration of common carotid arteries structure and elastic function in patients with HTG,which is a significant method of testing early alteration of carotid elastic in patients with HTG.

关 键 词：超声 高甘油三脂 颈动脉 早期 

分 类 号：R445.1[医药卫生—影像医学与核医学] R589.2[医药卫生—诊断学]