黑青稞籽皮提取物提高小鼠耐缺氧及抗疲劳能力的初步研究  

Preliminary study of black barley pericarp extract on the ability of anti-hypoxia and anti-fatigue of mice

作　　者：贺敏[1] 王庆军 丁雪洁[1] 李伟静[1] 任素萍[1] 阿沛.任鹏 郭彦 薛萍 王璇琳[1] 于群[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850 [2]神舟生物科技有限责任公司,内蒙古呼和浩特010206 [3]西藏蕃业飞虹科技有限公司,西藏拉萨850001 [4]解放军第三〇五医院,北京100017

出　　处：《中国医药导报》2014年第28期7-10,共4页China Medical Herald

基　　金：国家科技重大专项课题(编号20112XJ9302)

摘　　要：目的研究黑青稞籽皮提取物对小鼠耐缺氧及抗疲劳能力的影响。方法采用小鼠动物实验,分别研究黑青稞籽皮提取物对常压耐缺氧、亚硝酸钠中毒、急性脑缺血小鼠存活时间的影响以及通过对异丙肾上腺素增加心肌耗氧、失血性休克小鼠心搏时间的影响的观察评价其耐缺氧。利用负重游泳实验评价其抗疲劳功能。结果与生理盐水组比较,黑青稞籽皮提取物在3.5 g/kg剂量条件下显著延长常压耐缺氧小鼠的存活时间(P<0.01),在4.0 g/kg剂量条件下能够有效延长断头小鼠喘气时间(P<0.05),在2.0 g/kg剂量条件下能够延长小鼠负重游泳时间(P<0.05)。结论黑青稞籽皮提取物具有提高小鼠耐缺氧及抗疲劳能力的作用。Objective To study the effects of black barley pericarp extract on the ability of anti-hypoxia and anti-fatigue of mice. Methods The effects of black barley pericarp extract on survival time of mice with anoxia endurance under normal pressure, sodium nitrite poisoning, acute cerebral ischemia. Injecting isoprenaline and hemorrhagic shock were used to assess the function of anoxia endurance, tests of burdened swimming were used to assess the function ofanti-fatigue. Results Compared with normal saline group, the black barley pericarp extract significantly prolonged the survival time of mice under hypoxia condition with 3.5 g/kg dose （P〈0.01）, and effectively prolonged gasp time of beheaded mice with 4.0 g/kg dose （P 〈0.05）, and prolonged the swimming time of mice by the extract of black barley pericarp with 2.0 g/kg dose （P 〈0.05）. Conclusion Black barley pericarp extract can enhance the function of anti-fatigue and anoxiaendurancein mice.

关 键 词：黑青稞 籽皮提取物 耐缺氧 抗疲劳 小鼠 

分 类 号：R284[医药卫生—中药学]