对不同剂量连续血液净化治疗脓毒症的新认识  

New progress in different doses of continuous blood purification therapy in sepsis

作　　者：纪健[1] 钱素云[1] 

机构地区：[1]首都医科大学附属北京儿童医院重症医学科, 100045

出　　处：《中华实用儿科临床杂志》2014年第18期1413-1416,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家科技支撑计划（2013BAI04B01）

摘　　要：儿童脓毒症/严重脓毒症是儿童重症监护室中一种常见且病死率较高的疾病;细胞因子的“瀑布式”级联反应是导致病情持续恶化的主要原因.持续血液净化治疗技术可利用吸附及滤过等原理清除炎性介质,能够重建免疫稳态、降低患儿病死率.但目前,持续血液净化高、低剂量疗效的结论不同,对不同剂量的选择存在争议.现从不同角度介绍血液净化高、低剂量的效果,分析不同效果的影响因素.Spesis/severe sepsis remains a serious problem in pediatric intensive care unit.The mortality of sepsis/severe sepsis is still very high.The ＆quot;waterfall＆quot; cascade reaction of cell factors is the main reason leading to the continued deterioration of the condition.Continuous blood purification technology can not only remove inflammatory mediators by adsorption and filtration function,but also improve the immune function,even reduce the mortality rate.But there is a controversial topic on the selection of the appropriate dose.This review not only introduces the effects of high-volume hemofiltration and low-volume hemofiltration from different aspects,but also analyses the influencing factors of different effects.

关 键 词：连续血液净化治疗 高容量血液滤过 低容量血液滤过 脓毒症 严重脓毒症 儿科 

分 类 号：R720.597[医药卫生—急诊医学]