痢菌净与6种抗菌药对鸡大肠埃希菌的体外联合药敏试验研究  

The Drug Susceptibility Test in vitro of Six Antimicrobial Drugs Combine Mequindox to Escherichia coli from Chicken

作　　者：杨志坤 崔笑博 解相霞 郭树源[2] 宋道桢 常维山[2] 

机构地区：[1]山东省兽药质量检验所,济南250022 [2]山东农业大学动物医学院,泰安271018 [3]山东省滨州畜牧兽医研究院,滨州256600

出　　处：《国外医药（抗生素分册）》2014年第5期213-215,共3页World Notes on Antibiotics

基　　金：山东省农业产业技术创新体系家禽创新团队环境与生产岗位基金SDAIT-13-011-11

摘　　要：研究痢菌净分别和6种抗菌药联用在体外对鸡大肠埃希菌的抑制效果,为临床联合用药提供试验依据。采用棋盘微量测定法,痢菌净分别与头孢噻肟钠、阿奇霉素、粘杆菌素、新霉素、氟苯尼考组合,观察对大肠埃希菌的抑菌效果。结果表明痢菌净与头孢噻肟钠的联合使用对大肠埃希菌标准株、临床分离株呈协同作用为主(76.9%);痢菌净和新霉素联用呈协同或相加作用(协同占46.15%,相加占53.85%);痢菌净和氟苯尼考联用为相加作用(84.6%);痢菌净和粘杆菌素联用主要呈相加作用(相加作用76.9%,协同作用23.1%);痢菌净和左旋氧氟沙星、痢菌净和阿奇霉素联用呈无关作用。We studied six antimicrobial drugs to combine mequindox and observed the inhibitory effect for chicken Escherichia coli in vitro. It may provide a experiment basis for to treatment in clinical with drug combination. The chessboard trace determination method was adopted, mequindox respectively with cefotaxime sodium, azithromycin, colistin, neomycin, fluorine benzene nicol combination, antibacterial effect to E. coli bacteria was observed. Results shew that using mequindox in combination with cefotaxime sodium present synergy dominated （76.9%） for E. coli strains, clinical isolates; mequindox and neomycin combine each other to present synergistic or additive effect （synergistic accounting for 46.15%, additive accounted for 53.85%）; mequindox and fluorine benzene nicol joint use to present additive effect （84.6%）; mequindox and colistin jointly used to present additive effect primarily（additive accounted for 76.9% synergy accounted for 23.1%）; mequindox and levofloxacin, mequindox joint and azithromycin combine to present unrelated effect.

关 键 词：痢菌净 鸡大肠埃希菌 联合抗菌效果 

分 类 号：R978.1[医药卫生—药品]