白果提取物抗肿瘤作用的研究  

Antitumor Effects of Ginkgo Extract

作　　者：孟凡瑞[1] 刘波[2] 李晓秀[2] 刘洋[1] 孔玉梅[1] 王丹[1] 

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]沈阳医学院,辽宁沈阳110034

出　　处：《辽宁大学学报（自然科学版）》2014年第3期286-288,共3页Journal of Liaoning University：Natural Sciences Edition

摘　　要：为研究白果是否具有抗肿瘤作用,实验通过体外培养肝癌BEL7402细胞和胰腺癌PANC-1细胞,采用5-氟尿嘧啶(5-Fu)作为阳性对照药,评价白果提取物不同组分对肿瘤细胞生长的作用.在实验中,阳性对照药5-Fu具有较好的抗肿瘤作用,对肝癌BEL7402的IC50值为65.77μg/mL,对胰腺癌PANC-1细胞的IC50值为77.87μg/mL;白果提取物的正丁醇和水相组分能够抑制BEL7402细胞和PANC-1细胞生长,而多糖组分和乙酸乙酯组分有较弱的促进两种细胞生长作用.因此,银杏提取物水相和正丁醇组分对肝癌BEL7402细胞和胰腺癌PANC-1细胞具有抑制作用.To study the antitumor effects of Ginkgo extracts, the experiment cultured liver cancer BEL7402 cells and pancreatic cancer PANC - 1 cells, and tested the anti-tumor effects of different Ginkgo extract components with 5- fluorouracil （5-Fu） as positive drug. In the present study,positive drug 5-Fu has better antitumor effects, IC_50 of BEL7402 cells was 65.77 μg/mL and IC_50 of PANC-1 cells was 77.87 μg/mL, and butanol part and aqueous part of Ginkgo extracts had inhibition effects to BEL7402 cells and PANC-1 cells, while the polysaccharide component and ethyl acetate had a weak role in promoting the growth of two types of cells. Therefore, Ginkgo extracts may have antitumor effects.

关 键 词：白果 提取物 抗肿瘤作用 

分 类 号：R962[医药卫生—药理学]