心型脂肪酸结合蛋白、肌钙蛋白Ⅰ与脑卒中继发性肺栓塞的关系  

Association between heart-type fatty acid binding protein, cardiac troponin Ⅰ and stroke-associated pulmonary embolism

作　　者：韩芳 张伟东 廖晓凌[3] 王拥军[3] 

机构地区：[1]北京通州区潞河医院呼吸与危重症医学科,北京101101 [2]北京通州区潞河医院神经内科,北京101101 [3]北京天坛医院神经内科,北京100050

出　　处：《中国医药导报》2014年第27期39-41,共3页China Medical Herald

基　　金：国家重点基础研究发展计划(973计划)资助项目(编号2009CB521900)

摘　　要：目的探讨心型脂肪酸结合蛋白(H-FABP)联合肌钙蛋白Ⅰ(cTnⅠ)对脑卒中继发性肺栓塞患者早期诊断及判断预后的价值。方法选取2011年1月~2014年4月北京市通州区潞河医院收治的150例脑卒中继发性肺栓塞患者(研究组)及单纯脑卒中患者150例(对照组)。检测并比较治疗前两组及研究组治疗前后H-FABP、cTnⅠ水平。结果治疗前研究组H-FABP[(9.52±2.67)μg/L]及cTnⅠ[(0.15±0.09)μg/L]水平明显高于对照组[(3.87±2.96)、(0.05±0.03)μg/L],差异均有统计学意义(P<0.05);治疗后研究组患者血浆H-FABP、cTnⅠ水平分别为(5.51±1.97)、(0.08±0.03)μg/L,较治疗前明显降低,差异均有统计学意义(P<0.05)。结论脑卒中继发性肺栓塞患者血浆H-FABP及cTnⅠ浓度明显升高,两指标联合有助于脑卒中继发性肺栓塞的早期诊断和短期预后情况的评估。Objective To investigate the diagnosis and prognostic value of heart-type fatty acid binding protein com- bined cardiac troponin I in stroke-associated pulmonary embolism patients. Methods 150 patients with stroke-asso- ciated pulmonary embolism （study group） and 150 patients of stroke without pulmonary embolism （control group） from January 2011 to April 2014 in Luhe Hospital of Tongzhou District in Beijing City were selected in this study. The H- FABP and cardiac troponin I of patients in two groups before treatment and those of the study group after treatment were detected and compared. Results The levels of plasma H-FABP and cardiac troponin I of patients before treat- ment in study group [（9.52~2.67）, （0.15_＋0.09） ~g/L ] were higher than those of the control group [（3.87_＋2.96）, （0.05_＋ 0.03） Ixg/L], the differences were statistically significant （P 〈 O.05）.After treatment, the levels of plasma H-FABP and cardiac troponin I in study group [（5.5l_＋1.97）, （0.08_＋0.03） p^g/L] were decreased than pretreatment, the differences were statistically significant （P 〈 0.05）. Conclusion The level of H-FABP and cardiac troponin I increasing obviously in stroke-associated pulmonary embolism, and the detection of the two indexs can be helpful for the disease diagnosis and the access of short-time prognosis.

关 键 词：肺栓塞 脑卒中 心型脂肪酸结合蛋白 肌钙蛋白I 诊断 预后 

分 类 号：R542.22[医药卫生—心血管疾病]