甲状腺激素对多囊卵巢综合征患者卵泡生长的影响  

Effects of thyroid hormones on follicular growth of patients with polycystic ovary syndrome

作　　者：刘萍[1] 刘洋[2] 顾笑梅[3] 

机构地区：[1]河北联合大学附属医院妇产科,河北唐山063000 [2]河北联合大学冀唐学院 [3]唐山市妇幼保健院

出　　处：《中国妇幼保健》2014年第28期4555-4557,共3页Maternal and Child Health Care of China

基　　金：河北省科技计划项目〔12277736〕

摘　　要：目的:探讨血清甲状腺激素水平对于诱发排卵的多囊卵巢综合征(PCOS)患者卵泡生长的影响。方法:应用经克罗米芬+人绒毛膜促性腺激素(CC/hCG)诱导PCOS患者(89例)卵泡生长,根据卵泡生长情况分为卵泡生长正常组(49例)及卵泡生长障碍组(40例)。在排卵周期测定卵泡不同时间的大小及相应血清甲状腺激素(TSH)含量,对结果进行统计学分析。结果:卵泡生长的第0、5、10天,两组卵泡生长大小、T3和T4水平差异均无统计学意义(P均>0.05);卵泡生长第15天,卵泡生长障碍组卵泡大小〔(15.41±0.11)mm〕、血清T3〔(1.97±0.17)nmol/L〕、T4〔(97.43±0.16)nmol/L〕均低于卵泡生长正常组〔(19.18±0.19)mm,(2.69±0.15)nmol/L,(124.38±0.29)nmol/L,t=-0.886,-1.823,-1.745,P均<0.05〕,障碍组TSH水平〔(3.43±0.10)μIU/ml〕高于正常组〔(1.38±0.18)μIU/ml〕,两组比较,差异有统计学意义(t=-1.923,P<0.05)。结论:卵泡生长障碍组PCOS患者TSH水平较低,甲状腺激素水平低下在一定程度上影响卵泡生长。Objective： To explore the effects of serum thyroid hormones levels on follicular growth of patients with polycystic ovary syndrome （PCOS） treated by induced ovulation. Methods： Clomiphene （CC） and human ehorionic gonadotropin （hCG） were used to in- duce follicular growth in 89 patients with PCOS, then the patients were divided into normal follicular growth group （49 patients） and follicle growth disorder group （40 patients ） according to follicular growth situations. The sizes of follicles and the concentrations of serum thyroid hormones at different times during ovulatory cycle were measured, the results were analyzed statistically. Results： There was no statistically significant difference in the sizes of follicles, the levels of triiodothyronine （ T3 ） and tetraiodothyronine （ T4 ） at 0, 5, 10 days of follicular growth between the two groups （ P 〉 0. 05 ） ; on the fifteenth day of follicular growth, the size of follicles, serum T3 level and T4 level in folli- cle growth disorder group were （ 15.41 ±0. 11 ） ram, （ 1.97±0. 17） nmoL/L and （97.43 ±0. 16） nmol/L, respectively, which were statis- tically significantly lower than those in normal follicle growth group [ （19. 18 ± 0. 19） mm, （2. 69 ± 0. 15） nmol/L, （124. 38 ±0. 29） nmol/L] （ t = - 0. 886, P 〈 0. 05 ; t = - 1. 823, P 〈 0. 05 ; t = - 1. 745, P 〈 0. 05 ） . Thyroid stimulating hormone （TSH） level in follicle growth disorder group was （3.43 ＋ 0. 10 ） μIU/ml, which was statistically significantly higher than that in normal follicle growth group （ （ 1.38 ± 0. 18 ） μIU/ml] （ t = - 1. 923, P 〈 0.05 ） . Conclusion： TSH level in patients with follicle growth disorder is relatively low, the decreases of thyroid hormones levels may affect follicular growth to a certain extent.

关 键 词：多囊卵巢综合征 甲状腺激素 诱发排卵 

分 类 号：R714.147[医药卫生—妇产科学]