人参皂苷Rh2抗白血病作用机理的研究进展  

Research Progress of mechanism induced by Ginsenoside Rh2 in leukemia

作　　者：夏婷[1,2] 许吕宏[2] 方建培[2] 

机构地区：[1]吉林大学珠海学院,广东珠海519041 [2]中山大学第二附属医院,广东广州510120

出　　处：《时珍国医国药》2014年第9期2209-2211,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81100370)

摘　　要：目的将人参皂苷Rh2对白血病的抗肿瘤作用机理作以综述。方法查阅国内外相关资料并对人参皂苷Rh2对白血病的抗肿瘤作用机理进行整理、归纳。结果人参皂苷Rh2是人参中抗肿瘤的主要有效成分。能抑制白血病细胞增殖、促进凋亡、诱导分化、增加化疗药物的敏感性和逆转耐药等作用,而且具有毒副作用小,能提高机体免疫力,不易产生耐药性等优点。结论随着人参皂苷Rh2对白血病细胞的作用机制的不断阐明,为白血病治疗提供新的思路。Objective To review the antitumor mechanism induced by Ginsenoside Rh2 in leukemia. Methods Looked through the related information and references from domestic and abroad,analyzed and reviewed the antitumor mechanism of Ginsenoside Rh2. Results Ginsenoside Rh2 is a chief effective anti-tumor ingredients in ginseng. It has been reported to have various biological effects including anti-tumor activity on different mammalian tumor cells,meanwhile it has the advantages of little side effects,immunity promotion and not easy to produce drug resistance. Conclusion Further research should be carried out to fully investigate these mechanisms and provide a new way for the treatment of leukemia.

关 键 词：人参皂苷RH2 白血病 作用机理 

分 类 号：R285.5[医药卫生—中药学]