Two new b-hydroxy amino acid-coupled secoiridoids from the flower buds of Lonicera japonica:Isolation,structure elucidation,semisynthesis,and biological activities  

作　　者：Wei-Xia Song Yong-Chun Yang Jian-Gong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College

出　　处：《Chinese Chemical Letters》2014年第9期1215-1219,共5页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China (NNSFC; Nos.20772156 and 30825044);the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT,No.IRT1007);the National Science and Technology Project of China (Nos.2012ZX09301002-002 and 2011ZX0 9307002-01)

摘　　要：Two new β-hydroxy amino acid-coupled secoiridoids, named serinosecologanin （1） and threoninose- cologanin （2）, were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their uncommon structures including absolute configurations were determined by spectroscopic data analysis, and confirmed by semisynthesis from the co-occurring secologanin （3） and secologanic acid （4）. Compounds 1 and 2 exhibited resistant activity against β-glucosidase from almonds and hesperidinase from Aspergillus niger, they also showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor with inhibition rates of （34.9 ±3.1 ）% and （53.6 ± 2.6）%, respectively.Two new β-hydroxy amino acid-coupled secoiridoids, named serinosecologanin （1） and threoninose- cologanin （2）, were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their uncommon structures including absolute configurations were determined by spectroscopic data analysis, and confirmed by semisynthesis from the co-occurring secologanin （3） and secologanic acid （4）. Compounds 1 and 2 exhibited resistant activity against β-glucosidase from almonds and hesperidinase from Aspergillus niger, they also showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor with inhibition rates of （34.9 ±3.1 ）% and （53.6 ± 2.6）%, respectively.

关 键 词：Lonicera japonicaCaprifoliaceae β-Hydroxy amino acid-coupled secoirridoidIsolationStructure elucidationSemisynthesisBiological activity 

分 类 号：R284.1[医药卫生—中药学]