Bi(OTf)3-catalyzed tandem reaction of naphthols with β,γ-unsaturated a-ketoesters.Efficient synthesis of functionalized 4H-chromenes  

作　　者：Hui-Jing Li Dong-Hui Luo Qin-Xi Wu Chun-Yang Dai Zhi-Lun Shen Yan-Chao Wu 

机构地区：[1]School of Marine Science and Technology,Harbin Institute of Technology at Weihai [2]Beijing National Laboratory for Molecular Sciences (BNLMS),and Key Laboratory of Molecular Recognition and Function,Institute of Chemistry Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》2014年第9期1235-1239,共5页中国化学快报（英文版）

基　　金：supported by the Science and Technology Development Project of Weihai (Nos.2011DXGJ13,2012DXGJ02);the Natural Science Foundation of Shandong Province (No.ZR2012BM002);the National Natural Science Foundation of China (Nos.21202028,21372054)

摘　　要：An efficient synthesis of functionalized 4H-chromenes by the tandem reaction of β,γ-unsaturated α- ketoesters with 2-naphthols, 1 -naphthols, and 1,3-dihydroxynaphthalenes has been accomplished with high selectivity and excellent yields in the presence of a catalytic amount of bismuth triflate [Bi（OTf）3, 5 mol%] under mild conditions. The functionalized 4H-chromene synthesis and our previous 2H- chromene hemiacetal synthesis could complement each other to enrich reaction diversity.An efficient synthesis of functionalized 4H-chromenes by the tandem reaction of β,γ-unsaturated α- ketoesters with 2-naphthols, 1 -naphthols, and 1,3-dihydroxynaphthalenes has been accomplished with high selectivity and excellent yields in the presence of a catalytic amount of bismuth triflate [Bi（OTf）3, 5 mol%] under mild conditions. The functionalized 4H-chromene synthesis and our previous 2H- chromene hemiacetal synthesis could complement each other to enrich reaction diversity.

关 键 词：Bismuth triflate 4H-Chromenes Tandem reaction Selective synthesis 

分 类 号：O621.3[理学—有机化学]