Panthogenins A and B,two novel norergostanol steroids from Dioscorea panthaica  

作　　者：Xiao-Qing Shan Shu-Lin Peng Hai-Li Shi Xiao-Ling Wang Li-Sheng Ding Xun Liao 

机构地区：[1]Chengdu Institute of Biology,Chinese Academy of Sciences [2]Ethnic Pharmaceutical Institute,Southwest University for Nationalities

出　　处：《Chinese Chemical Letters》2014年第9期1256-1258,共3页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China (Nos.21072184,30973634 and 81173536)

摘　　要：Two novel 27-norergostanol steroids, panthogenins A （1） and B （2）, possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.Two novel 27-norergostanol steroids, panthogenins A （1） and B （2）, possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.

关 键 词：Dioscorea panthaica DIOSCOREACEAE Norergostanol steroids Structural elucidation Insulin sensitizing activity 

分 类 号：R284.2[医药卫生—中药学] O629.2[医药卫生—中医学]