Effects of oxaliplatin on DNA condensation  

作　　者：JU HaiPeng ZHANG HongYan LI Wei WANG PengYe 

机构地区：[1]Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics,Institute of Physics,Chinese Academy of Sciences

出　　处：《Science China(Physics,Mechanics & Astronomy)》2014年第11期2114-2120,共7页中国科学：物理学、力学、天文学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.11104341 and 11274374);the National Basic Research Program of China(Grant No.2013CB837200)

摘　　要：In this paper the interactions between DNA and anti-cancer drug oxaliplatin were investigated by using magnetic tweezers.The dynamics of DNA condensation due to oxaliplatin was traced under various forces.It is found that torsion constraint in DNA enhances the ability of oxaliplatin for shortening DNA.The transplatin helps oxaliplatin combine to DNA and increase the rate of DNA condensation.All these results are consistent to the previously proposed model and are helpful for further investigation of interaction between DNA and oxaliplatin.In this paper the interactions between DNA and anti-cancer drug oxaliplatin were investigated by using magnetic tweezers.The dynamics of DNA condensation due to oxaliplatin was traced under various forces.It is found that torsion constraint in DNA enhances the ability of oxaliplatin for shortening DNA.The transplatin helps oxaliplatin combine to DNA and increase the rate of DNA condensation.All these results are consistent to the previously proposed model and are helpful for further investigation of interaction between DNA and oxaliplatin.

关 键 词：DNA condensation shortening torsion helpful constraint cisplatin analogues tethered traced 

分 类 号：Q523[生物学—生物化学]