千金文武汤对糖尿病肾病大鼠血糖和肾功能的影响  

Effect of Qianjinwenwutang on blood glucose and renal function of diabetic nephropathy rats

作　　者：卢焕俊 金元哲[1] 许青松[1] 

机构地区：[1]延边大学生理学教研室,吉林延吉133002

出　　处：《山东医药》2014年第33期17-19,共3页Shandong Medical Journal

基　　金：吉林省卫生厅卫生科研课题(2012Z128)

摘　　要：目的探讨朝医方千金文武汤对糖尿病肾病(DN)模型大鼠血糖和肾功能的影响,并探讨其作用机制。方法将SD大鼠麻醉后,结扎肾动脉,切除左肾脏,同时注射链尿佐菌素制备DN模型,将造模成功的大鼠随机分为千金文武汤低、中、高剂量组和模型组、阳性对照组各10只,另设正常对照组10只,行假手术处理。术后各组分别给予2.5、5、10 g/kg千金文武汤和蒸馏水、洛丁新、蒸馏水灌胃,1次/d,连续30 d。观察各组基本状态及24 h尿量、空腹血糖、血尿素氮、肌酐、肌酐清除率。结果模型组24 h尿量、空腹血糖、血尿素氮、肌酐和肌酐清除率均高于千金文武汤各剂量组(P均<0.05),千金文武汤各剂量组与阳性对照组比较均无统计学差异(P均>0.05)。结论千金文武汤对DN模型大鼠具有治疗作用,能够显著抑制DN模型大鼠肾脏病理变化,其机制可能与其药物组分降低血糖和调节肾小球的滤过率有关。Objective To investigate effect of Korean medicine ＆#39;Qianjinwenwutang＆#39;on blood glucose and renal function of rats with diabetic nephropathy and discuss its possible mechanism .Methods 120 SD rats were established diabetic ne-phropathy model though ligation of Renal artery , resection of the left kidney and injection of cephalosporins after anesthe-sia.50 successfully established rats were divided into Qianjinwenwutang low , middle, high dose group, model group and positive control group , 10 rats in each groups , treated with left nephrectomy .Ten healthy rats who underwent sham opera-tion were as normal control group .These rats were keeping on intragastric administration of puff ginseng suspension （2.5 g/kg, 5 g/kg, 10 g/kg） and distilled water for 30 d.The basic state, 24 h urine, fasting blood glucose, blood urea nitro-gen, creatinine and creatinine clearance were observed and compared （all P〈0.05）.Results The 24 h urine, fasting blood glucose , blood urea nitrogen , creatinine and creatinine clearance of rats in model group were higher than those of rats in drug group .Conclusions Medicine＆#39;Qianjinwenwutang＆#39;has a function on diabetic nephropathy in rats and can inhibit re-nal pathological changes , which may be related to decrease blood sugar and adjustment of the glomerular filtration rate .

关 键 词：糖尿病肾病 千金文武汤 血糖 肌酐 大鼠 

分 类 号：R587.2[医药卫生—内分泌]