PPARγ基因多态性与维吾尔族高血压的关联性研究  

Association of PPARγ gene polymorphism with hypertension in Xinjiang Uygur

作　　者：陈娟[1] 张眉[1] 刘佳铭[1] 马儒林[1] 郭恒[1] 牛强[1] 丁玉松[1] 张景玉[1] 郭淑霞[1] 

机构地区：[1]新疆石河子大学医学院预防医学系,832000

出　　处：《实用医学杂志》2014年第18期2922-2925,共4页The Journal of Practical Medicine

基　　金："十一五"国家科技支撑计划(编号:2009BAI82B04)

摘　　要：目的:探讨PPARγ基因rs1801282、rs3856806及rs4684847多态性与维吾尔族高血压的关系。方法:应用基质辅助激光解析电离时间飞行质谱(MALDI-TOF-MS)技术检测145例高血压患者和165例对照者PPARγ基因rs1801282、rs3856806及rs4684847基因型。结果 :(1)高血压组rs1801282基因CC基因型和C等位基因频率分别为75.9%和87.2%,均高于对照组的63.6%、79.7%(P<0.05);(2)对其进行风险分析后,携带rs1801282基因GG基因型和CG基因型的个体患高血压的风险分别是携带CC基因型的0.273及0.594倍,携带C等位基因的个体患高血压的风险是携带G等位基因的1.742倍;(3)多因素logistic回归分析显示,rs1801282基因多态性、超重及肥胖是高血压发生的危险因素。(4)高血压组rs3856806及rs4684847基因型和等位基因频率与对照组相比差异均无统计学意义(均P>0.05)。(5)rs1801282 CC基因型携带者SBP高于CG/GG基因型携带者,但TC较CG/GG基因型携带者低(P<0.05)。结论:维吾尔族人群携带PPARγ基因rs1801282位点的CC基因型和C等位基因的个体患高血压的风险升高。rs3856806及rs4684847多态性与维吾尔族人群高血压无关。Objective To investigate the relationship between polymorphisms of PPARy gene（rs1801282, rs3856806 and rs4684847） and hypertension in Uygnr. Methods Polymorphisms of PPARγ gene,rs1801282, rs3856806 and rs4684847, were identified in 145 hypertension patients and 165 healthy volunteersby matrix-assisted laser desorption-ionization time-of-flight mass spectrometry （MALDI-TOF-MS）. Results（1）Frequencies of rs1801282 CC genotype and C allele were 75.9% and 87.2% in hypertension grouprespectively, which were higher than those in control group （63.6% and 79.7%, respectively, P 〈 0.05）;（2） After risk analysis, individuals with GG and CG genotypes of rs1801282 had 0.273 and 0.594 times higherrisks to develop hypertension than those with CC genotype respectively, while individuals with C allele had 1.742times higher risk to develop hypertension than those with G allele; （3） Multivariate logistic regression analysisshowed that polymorphism of rs1801282, overweight and obesity were risk factors for the incidence ofhypertension. （4） No significant differences in both frequencies of rs3856806 and rs4684847 genotypes andallele were noted between hypertension group and control group （P 〉 0.05）. （5） SBP in rs1801282 CC genotypecarriers was higher than in CG/GG gene ones, whereas TC was opposite （P 〈 0.05）. Conclusions In theUygur, individuals with CC genotype and C allele at rs1801282 of PPARγ gene are at higher risk ofhypertension. Polymorphism of rs3856806 and rs4684847 may be irrelevant with hypertension in the Uygur.

关 键 词：维吾尔族 高血压 PPARΓ基因 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]