铜绿假单胞菌制剂治疗恶性胸腔积液疗效和安全性的Meta分析  

Therapeutic Efficacy and Safety of Pseudomonas aeruginosa Preparations for Malignant Pleural Effusion:A Meta-analysis

作　　者：杨兴缨 高明太[2,3] 焦海胜[1] 肖吉元[1] 

机构地区：[1]兰州大学第二医院药剂科,兰州730000 [2]兰州大学第一医院小儿外科,兰州730000 [3]兰州大学循证医学中心,兰州730000

出　　处：《中国药房》2014年第36期3396-3399,共4页China Pharmacy

摘　　要：目的:系统评价铜绿假单胞菌制剂(PAI)治疗恶性胸腔积液的疗效和安全性,以为临床提供循证参考。方法:计算机检索Cochrane Library、PubMed、EMBase、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库中关于PAI治疗恶性胸腔积液的随机对照试验(RCT),对纳入的RCT采用Cochrane协作网提供的Rev Man 5.2.9统计软件进行Meta分析。结果:共纳入9项RCT,合计546例患者。Meta分析结果显示,试验组患者完全缓解率[RR=1.65,95%CI(1.25,2.17),P<0.000]、部分缓解率[RR=1.49,95%CI(1.20,1.85),P<0.000]、稳定率[RR=0.42,95%CI(0.30,0.58),P<0.000]、进展率[RR=0.35,95%CI(0.19,0.64),P<0.000]均显著优于对照组,两组比较差异有统计学意义。亚组分析显示,两组患者不良反应发生率比较差异无统计学意义[RR=1.15,95%CI(0.91,1.46),P>0.05;RR=0.61,95%CI(0.32,1.17),P>0.05]。结论:PAI治疗恶性胸腔积液可以提高临床疗效,降低不良反应发生率,但该结论仍需要高质量、大样本的RCT进一步来验证。OBJECTIVE：To evaluate the therapeutic efficacy and safety of Pseudomonas aeruginosa preparations（PAI）for malignant pleural effusion systematically,and to provide evidence-based reference for clinical use. METHODS：Retrieved from Cochrane library,Pubmed,EMBase,CBM,CNKI,VIP and Wanfang database,RCTs about PAI for malignant pleural effusion were selected. Meta-analysis of included RCTs were conducted by using Rev Man 5.2.9 statistical software provided by Cochrane collaboration net. RESULTS：9 RCT were included,involving 546 patients. Meta-analysis showed that the rate of CR [RR=1.65,95%CI（1.25,2.17）,P〈0.000],PR [RR=1.49,95%CI（1.20,1.85）,P〈0.000],SD [RR=0.42,95%CI（0.30,0.58）,P 0.000] and PD [RR=.35,95%CI（0.19,0.64）,P〈0.000] in trial group were significantly better than in control group;there was statistical significance. There was no statistical significance in ADR between 2 groups in subanalysis[RR=1.15,95%CI（0.91,1.46）,P0.05;RR=0.61,95%CI（0.32,1.17）,P〉0.05]. CONCLUSIONS：PAI can improve the therapeutic efficacy and decrease the incidence of ADR for malignant pleural effusion. While large-scale and high-quality RCTs are still needed to support this conclusion.

关 键 词：铜绿假单胞菌制剂 恶性胸腔积液 顺铂 META分析 疗效 安全性 

分 类 号：R979.1[医药卫生—药品]