血栓通注射剂致不良反应76例文献分析  

Literature Analysis of 76 Cases of Xueshuantong Injection-induced ADR

作　　者：周福永[1] 蔡志琴[1] 胡金芝[1] 

机构地区：[1]浙江省台州医院,浙江临海317000

出　　处：《中国药房》2014年第36期3431-3433,共3页China Pharmacy

摘　　要：目的:探讨血栓通注射剂致不良反应(ADR)的一般规律及特点,为临床合理用药提供参考。方法:检索中国期刊全文数据库、维普数据库、万方数据库2000-2013年收录的血栓通注射剂致ADR文献报道,对收集到的76例ADR的相关情况进行分类、归纳、统计、分析。结果:76例ADR中,59例(占77.63%)在用药30 min内发生,以即发型和速发型过敏反应为主;累及器官/系统以全身性损害(占43.71%)、神经系统损害(占19.21%)、呼吸系统损害(占17.88%)为主;经停药及对症治疗后均治愈或好转。结论:通过提高药品质量并加强用药过程监测等措施,可避免和减少其ADR的发生。OBJECTIVE：To investigate the regularity and characteristics of ADR induced by Xueshuantong injection,and to provide guidance for rational drug use in the clinic. METHODS：Retrieved from CNKI,VIP and Wanfang database,related literatures about ADR induced by Xueshuantong injection from 2000 to 2013 were included. 76 included ADR cases were classified and summarized. RESULTS：Among 76 ADR cases,59 cases occurred within 30 min after medication（77.63%）,mainly were immediate allergy and anaphylactic type allergy;involved organs or systems were mainly systemic injury（43.71%）,nervous system damage（19.21%）,respiratory system damage（17.88%）;the symptoms were cured or improved after drug withdrawal and symptomatic treatment. CONCLUSIONS：The improvement of drug quality and medication process monitoring and other measures to avoid and reduce the occurrence of ADR.

关 键 词：血栓通注射剂 不良反应 文献分析 

分 类 号：R969.3[医药卫生—药理学]