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作 者:章晶晶[1] 范欣生[1] 杨环[1] 蒋辰雪[1] 李芸[1] 戚中华[1]
机构地区:[1]南京中医药大学,南京210046
出 处:《中华中医药杂志》2014年第9期2870-2873,共4页China Journal of Traditional Chinese Medicine and Pharmacy
基 金:国家重点基础研究发展计划(973计划)(No.2011CB505301);江苏高校优势学科建设工程资助项目(PAPD)~~
摘 要:"十八反"是中药配伍禁忌的核心内容,笔者收集整理近50年来十八反"诸参辛芍叛藜芦"的现代文献105篇,从理论探究、临床应用、实验研究3个方面综述其目前研究成果和现状,为临床安全用药提供依据。结果发现50年来中药"十八反"藜芦相反药物配伍禁忌的理论研究主要围绕"诸参"范围及其增损讨论;由于藜芦毒性较大,一般不作内服,其少数应用主要为外用,以藜芦-苦参治疗皮肤疾病应用为主。实验研究早期主要为以动物死亡为指标的整体实验,近年多观察关注反药物质基础研究及以细胞、分子生物学方法探究配伍毒性、药物代谢酶的变化等。结果提示利用现代生物技术进一步系统阐述反药禁忌相关机制和宜忌关系是该领域的研究重点,同时藜芦反药外治皮肤病的特殊运用及相关安全性也值得探讨。Eighteen incompatibility pairs are core contents in TCM incompatibility. The modern literatures about eighteen incompatibility pairs are collected in recent 50 years. It reviews the current results and status from three aspects of theory investigation, clinical application and experimental research, in order to provide evidence for clinical safe medication. The resultsfind that the discussion on theory of eighteen incompatibility pairs in recent 50 years mainly around on the participation and the scope in all kinds of ginsengs. Veratrum nigrum is mainly for external use instead of oral administration because of its great toxicity, Veratrum nigrum combined with Sophora flavescens is a common preparation for external use in curing skin diseases. Earlier studies focus on integral experiments whose primary index is the death of animal. In recent years, researchers explore its material base of antagonisms and variation of toxicity in compatibility and the drug's metabolic enzyme used by cellular and molecular biological methods. The results suggest that the mechanisms and relationships of eighteen incompatibility pairs are research priorities in the field, and need more further systematical elaboration by using modern biotechnology, meanwhile the special use and clinical safety of Veratrum nigrum and it's anti-drug for external use in curing skin diseases deserve further exploration and discussion.
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