中药提取物及单体治疗老年性痴呆的药理作用及机制的实验研究进展  

Experimental research progress on the pharmacological effects and mechanisms of TCM extracts and Chinese herbal monomer extracts in treating Alzheimer's disease

作　　者：韦云[1] 刘剑刚[1] 李浩[1] 唐旭东[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中华中医药杂志》2014年第9期2874-2876,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技重大专项"重大新药创制"项目(No.2009ZX09103-391);国家自然科学基金课题(No.81173383);北京市科学技术委员会"十病十药"研发(No.Z141100002214003)~~

摘　　要：针对老年性痴呆的中药研究已深入到细胞、蛋白质和基因水平,虽然中药提取物的有效组分复杂,中药单体的提取也面临着困惑和争议,但中药提取物和单体干预老年性痴呆的机制研究还是逐步深入。针对老年性痴呆的发病假说如β淀粉样蛋白级联学说、胆碱能学说、氧化应激、钙代谢紊乱等进行有针对性的体内和体外干预研究,恰恰展现了中药多靶点、多途径干预的优势。The researches about traditional Chinese medicine on senile dementia （also known as Alzheimer＇s disease, AD） have been deep into the cells, protein and gene level. Effective component of traditional Chinese medicine extracts has made up of multiple compounds, Chinese herbal monomer extracts are facing with perplexity and controversy, but the mechanism study of these in treating AD is deepening gradually. All of intervention studies in vivo and in vitro are aimed at hypothesis for the pathogenesis of AD, such as 13 -amyloid cascade theory, cholinergic hypothesis, oxidative stress, calcium metabolism disorder, and so on, which shows superiority in the medication of multi-factorial, multi-target action.

关 键 词：中药提取物 中药单体 老年性痴呆 研究进展 实验研究 

分 类 号：R285[医药卫生—中药学]