急性铅中毒对小鼠睾丸病理损伤研究  

Effect of acute lead poisoning on pathological damage in mice testis

作　　者：孙相和 孔令芸 李冲[1] 陈玲丽[1] 宁红梅[1] 葛亚明[1] 

机构地区：[1]河南科技学院,河南新乡453003

出　　处：《河南科技学院学报（自然科学版）》2014年第4期49-51,共3页Journal of Henan Institute of Science and Technology(Natural Science Edition)

基　　金：河南省基础与前沿项目(132300410353);河南省高等学校青年骨干教师资助计划(2011GGJS-134)

摘　　要：为了研究急性铅中毒对小鼠睾丸病理变化的影响,通过对小鼠饲喂含有醋酸铅的去离子水建立铅负荷小鼠模型.处理10 d后取材,分析体质量、睾丸指数和睾丸病理剖检变化.结果显示:与对照组相比,铅中毒组小鼠体质量无明显变化,睾丸指数降低,且差异显著(P<0.05);小鼠睾丸中支持细胞、生精细胞和间质细胞数量减少.铅对小鼠睾丸具有显著损害作用,从而影响小鼠的生殖健康.To investigate the effect of acute lead poisoning on pathological changes in mice testis,mice were orally administered with lead acetate for 10 days to establish a lead poisoning mice model.After 10 days,some indexes,such as body weight,testis index,necropsy and histopathology,were analyzed.The results showed that the body weight change of mice was not relevant significantly to the dosage of lead acetate.Compared with the control group,the difference of testis relative index in dosage group was significant （P＆lt;0.05）.The amount of sertoli cells,germ cells and Leydig’s cells in mice tesis was decreased.The results suggested that lead could damage mice testis significantly and then affect the reproductive health of mice.

关 键 词：铅中毒 小鼠 睾丸 病理变化 

分 类 号：S859.82[农业科学—临床兽医学]