水杨酸乙酯的绿色催化合成  

Eco-friendly synthesis of ethyl salicylate

作　　者：李启东[1] 袁旭宏[2] 叶余原[1] 黄海明[1] 陈红[1] 尤玉静[1] 熊双喜[1] 

机构地区：[1]台州学院医药化工学院,浙江台州318000 [2]台州职业技术学院生化系,浙江台州318000

出　　处：《化学工程师》2014年第8期12-13,57,共3页Chemical Engineer

基　　金：国家青年科学基金(21207095)

摘　　要：在NaHSO4·H2O复合催化剂的条件下,由乙醇和水杨酸为原料合成了较高收率水杨酸乙酯。该文研究了NaHSO4·H2O复合催化剂用量、乙醇使用量和反应时间,带水剂的选择等因素对催化合成水杨酸乙酯收率的影响。实验结果证明,当乙醇∶水扬酸摩尔比为5.5∶1和NaHSO4·H2O为1.8g,H2SO4在0.9g、带水剂6mL时,回流分水240~300min,酯收率达92.07%,为最佳反应条件。Higher yield ethyl salicylate was synthesized by alcohol and salicylic acid with sodium bisulfate as catalyst. The effects of dosage of composite catalyst, alcohol dosage, reaction time and selection of water-carrying agent on the yield were studied. The results showed that ester yields were up to 93.07% when conditions were fol-lowing：the mole ratio of alcohol：salicylic acid was 5.5∶1, sodium bisulfate was 1.8g, sulfuric acid was 0.9g, water-carrying agent was 6mL and refluxing 240~300min.

关 键 词：水杨酸乙酯 酯化反应 复合催化剂 催化 

分 类 号：TQ244.5[化学工程—有机化工]