女性绝经年限与代谢综合征的关系研究  

Relationship between women menopausal period and risk of metabolic syndrome

作　　者：李晓宇[1] 冯正平[1] 邓华聪[1] 瞿华[1] 王行[1] 魏慧丽[1] 邓敏[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《重庆医学》2014年第26期3471-3473,3477,共4页Chongqing medicine

基　　金：国家临床重点专科建设项目资助;重庆市医学科研计划项目(2009-2-392)

摘　　要：目的：探讨女性绝经年限与代谢综合征（M S ）的关系。方法选取重庆城市地区40岁以上女性为调查人群，对所有受试者进行问卷调查、体格检查，同时检测生化指标，最终有1402名自然绝经的女性纳入该研究。将研究对象按绝经年限小于5年、5～＜10年、10～＜15年、≥15年分组，采用Logistic回归分析绝经年限与MS及其组分的关系。结果该研究人群MS患病率为40．87％，患MS的女性绝经年限明显高于非MS者（P＜0．05）。绝经后女性MS患病率在绝经年限小于5年、5～＜10年、10～＜15年、≥15年分别为29．37％、34．29％、45．30％、49．13％（ P＜0．05）。校正年龄、BM I后（除中心性肥胖），绝经年限在10～＜15年组的M S的患病风险是绝经年限小于5年的1．54倍。当绝经年限大于或等于15年时，该风险进一步上升至1．71倍。Logistic回归分析显示，BMI及绝经年限是MS的影响因素。结论绝经后女性是MS的高危人群，且绝经年限与MS相关。Objective To explore the relationship between the women menopausal period and metabolic syndrome （MS） .Meth-ods The female residents of Chongqing urban areas above 40 years were selected as the investigation group ,all the subjects were performed the questionnaire survey and the physical examination ,at the same time the biochemical indexes were detected .Finally , 1402 women of natural menopause were included in this study .The study subjects were divided into different groups according to the menopausal period of 〈5 years ,5- 〈10 years ,10- 〈15 years and ≥15 years .The Logistic regression analysis was adopted to analyze the relationship between the menopausal period with MS and its components .Results The MS prevalence in this group was 40 .87% ,and the menopausal period of the women with MS was significantly higher than that without MS （P〈0 .05） .The MS prevalences of postmenopausal women in the menopause period of 〈5 years ,5 - 〈10 years ,10 - 〈15 years and ≥15 years were 29 .37% ,34 .29% ,45 .30% and 49 .13% respectively （P〈0 .05） .After adjustment for age and BMI （except central obesity ） ,the MS risk in the menopausal period of 10- 〈15 years and was 1 .54 times of that in the menopausal period of 〈5 years .The Logis-tic regression analysis showed that BMI and menopausal period were the influence factors of MS .Conclusion Post-menopausal women are the high-risk group of MS and the menopausal period is correlated to MS .

关 键 词：绝经年限 代谢综合征 血压 血糖 

分 类 号：R589[医药卫生—内分泌]