肿瘤坏死因子受体相关因子6在大鼠脑缺血再灌注损伤中的mRNA表达  

Change of expression of TRAF6 in rat cerebral ischemia and reperfusion

作　　者：袁平[1] 何晓英[1] 李小刚[1] 

机构地区：[1]泸州医学院附属医院神经内科,四川泸州646000

出　　处：《泸州医学院学报》2014年第4期367-369,共3页Journal of Luzhou Medical College

基　　金：四川省卫生厅课题(100272);泸州医学院课题(38)

摘　　要：目的:观察肿瘤坏死因子受体相关因子6(TRAF6)mRNA在大鼠脑缺血再灌注损伤中的表达变化。方法:构建大鼠脑缺血再灌注损伤模型,RT-PCR检测TRAF6的表达变化。结果:与假手术相比较,缺血组和再灌注组TRAF6 mRNA表达明显升高。结论:大脑遭受缺血再灌注损伤时,活化的TRAF6参与脑细胞死亡。Objective： To study the mRNA expression of TRAF6 in rat cerebral ischemi-reperfusion.Methods： Rat brain injury model was induced by ischemia-reperfusion. The change of expression of TRAF6 gene was examined by RT-PCR. Result： In comparison to sham group, the expression of TRAF6 was obviously increased both in ischemia group and in re-perfusion group. Conclusion： TRAF6 is involved in brain cell death induced by cerebral ischemia-reperfusion.

关 键 词：TRAF6 脑缺血-再灌注 细胞死亡 

分 类 号：R541.4[医药卫生—心血管疾病]