急性有机磷农药中毒与CD8^+CD28^+T细胞、CD8^+CD28^-T细胞相关性及意义  

Correlation and significance of acute organophosphorus pesticide poisoning with CD8^+CD28^+T cells, CD8^+CD28^-T cells

作　　者：彭广军[1] 杨伟红[1] 曹国辉[1] 常海哲[1] 贾雪梅[1] 

机构地区：[1]河北大学附属医院急诊医学科,河北保定071000

出　　处：《医学研究与教育》2014年第4期8-11,共4页Medical Research and Education

基　　金：保定市科学技术研究与发展计划项目(12ZF080)

摘　　要：目的探讨急性甲胺磷农药中毒早期血药浓度与T淋巴细胞亚群的关系。方法选择河北大学附属医院急诊医学科2007年1月至2013年6月收治的92例口服急性甲胺磷农药中毒患者,按中毒程度分为轻中度中毒组54例和重度中毒组38例,另选同期健康体检者92例为对照组,检测并分析中毒患者血药浓度与CD3+、CD8+、CD8+CD28+、CD8+CD28-的关系。结果重度中毒组血药浓度水平较轻中度中毒组明显高(P<0.01),CD3+、CD8+、CD8+CD28+细胞数较轻中度中毒组明显低(P<0.01),而CD8+CD28-细胞数较轻中度中毒组明显高(P<0.01)。结论急性甲胺磷农药中毒早期血药浓度越高,中毒程度愈重,细胞免疫受损越严重。Objective To investigate the early blood drug concentration correlations of acute methamidophos poisoning with T lymphocyte subsets. Methods 92 patients with acute methamidophos pesticide taken orally admitted into Affiliated Hospital of Hebei University between January, 2007 to June, 2013 were selected. According to the degree of poisoning, they were divided into mild, moderate poisoning group （54 cases） and severe poisoning group （38 cases）, another 92 healthy people who taken physical checkup as control group. Detection and analysis of the relationship between serum drug concentration and toxic CD3^＋, CD8^＋, CD8^＋CD28^＋, CD^8＋CD28^- were conducted. Results The concentration of blood drug level of severe poisoning group was significantly higher than that of mild and moderate poisoning group （P〈0.01）. CD3^＋, CD8^＋, CD8^CD28^＋ cell number were decreased significantly than that of mild and moderate poisoning group （P〈0.01）. but the number of CD8^＋CD28^＋ cells were significantly increased than that of mild and moderate poisoning group （P〈0.01）. Conclusion The higher the early blood drug concentration of acute methamidophos poisoning, the degree of poisoning is severer, the more seriously impaired the immune cells are.

关 键 词：甲胺磷 血药浓度 CD8^+CD28^+ CD8^+CD28^+- 

分 类 号：R595[医药卫生—内科学]