血浆脑钠肽的检测对急性心肌梗死患者的早期诊断价值  

The Early Diagnostic Value of Serum BNP Level in Patients with Acute Myocardial Infarction

作　　者：金霞[1] 马晶茹[1] 

机构地区：[1]沈阳医学院附属第二医院,辽宁沈阳110032

出　　处：《中国医学创新》2014年第26期3-6,共4页Medical Innovation of China

摘　　要：目的:探讨血浆BNP在急性心肌梗死患者发病后的动态变化及其对AMI的早期诊断价值。方法:选择稳定型心绞痛(SA)患者22例、不稳定型心绞痛(UA)患者24例及健康对照组20例测定血浆BNP浓度,急性心肌梗死(AMI)患者41例于症状发作后2、4、6、24 h测定血浆BNP浓度。结果:UA组及AMI各时间点BNP水平均明显高于SA组(P<0.01);且随着症状发作时间的延长而明显增高(P<0.01)。AMI患者症状发作4、6 h ROC曲线下面积分别为0.819和0.898。结论:AMI患者发病2 h血浆BNP就开始增高,且增高的水平与发病时间长短明显相关;血浆BNP用于早期诊断急性心肌梗死有非常好的诊断功能。Objective：To discuss the dynamic changes of BNP in the patients of AMI and the clinical significance of the early diagnosis of AMI. Method：Plasma BNP in 22 SA cases,24 UA cases,20 healthy cases were tested and the plasma BNP of 41 AMI cases also were tested in 2,4,6 and 24 h after the onset of AMI.Result：BNP level of AMI group and UA group were obviously higher than that of SA group（P〈0.01）.Plasma BNP level in 4,6,24 h after onset of AMI were obviously higher than that of UA group（P〈0.01）.4 h and 6 h after AMI onset the surface area under ROC curve were 0.819 and 0.898. Conclusion：AMI patients have an increased plasma BNP level obviously 2 hours after the onset of AMI,and the BNP level increases significantly with the extension of tine. 4 h and 6 h after the onset of AMI the plasma BNP level have good diagnostic value for AMI.

关 键 词：急性心肌梗死 脑钠肽 早期诊断 

分 类 号：R542.22[医药卫生—心血管疾病]