5-三氟甲基-2-茚酮的合成及表征  

Synthesis and characterization of 5-trifluoromethyl-2-indanone

作　　者：奉强[1] 何冰[1] 张琦[1] 张小玲[1] 李仲辉[2] 

机构地区：[1]成都师范学院化学与应用化学系,四川成都611130 [2]成都师范学院功能分子研究所,四川成都611130

出　　处：《化学研究与应用》2014年第9期1445-1449,共5页Chemical Research and Application

基　　金：四川省科技厅科技支撑计划项目(2009GZ0167;2012FZ0129)资助;成都师范学院项目(CS13ZB04)资助

摘　　要：三氟甲基化合物和茚酮化合物具有许多独特的理化性质和生物活性,在农药、医药、染料和功能材料领域应用广泛。以对三氟甲基苯甲醛为原料,经Knoevenagel缩合、分子内Friedel-Crafts酰化、环氧化物不对称开环等步骤,经9步反应以总收率22%得目标化合物5-三氟甲基-2-茚酮,其结构经1H NMR、13C NMR、DEPT、HR-ESI-MS和元素分析表征。Applications of compounds containing trifluoromethyl and indanone in the fields of pesticide,medicine,dyes and function-al materials were wide,because of their unique properties of physics and chemistry as well as excellent bioactivities. Herein the 5-trifluoromethyl-2-indanone was synthesized starting from 4-trifluoromethyl benzaldehyde with the Knoevenagel condensation,Friedel-Crafts acylation and asymmetric ring opening of epoxide as the key steps through nine steps in 22%overall yields,and the product was characterized by 1 H NMR,13 C NMR,HR-ESI-MS,element analysis and found to be in good agreement with its structure.

关 键 词：5-三氟甲基-2-茚酮 不对称开环 缩合 合成 

分 类 号：O624.42[理学—有机化学]