氨溴索支气管灌洗佐治支气管结核疗效观察  

Observation on efficacy of bronchialveolar lavage with ambroxol in the treatment of bronchial tuberculosis

作　　者：殷建团[1] 邱跃灵[1] 钱树苑[1] 

机构地区：[1]解放军第175医院呼吸结核科(厦门大学附属东南医院),福建漳州363000

出　　处：《临床肺科杂志》2014年第10期1841-1843,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察和评价氨溴索注射液支气管灌洗佐治支气管结核的疗效。方法选择早期炎症、渗出性支气管结核患者65例,随机分为两组。试验组33例(常规抗痨+支气管镜下灌洗盐酸氨溴索、左氧氟沙星氯化钠注射液2次/周)。对照组32例,(常规抗痨+支气管镜下灌洗左氧氟沙星氯化钠注射液2次/周)。结果试验组和对照组在强化期抗痨满1个月结核中毒症状缓解率分别为90.9%、71.9%(P<0.05)。强化期满3个月痰菌阴转率分别为87.9%、65.6%(P<0.05),肺不张治疗有效率分别为84.8%、62.5%(P<0.05);肺功能改善率为87.9%、65.6%(P<0.05)。结论在全身抗痨基础上,辅以盐酸氨溴索支气管灌洗可加快支气管结核痰菌转阴,较好减轻支气管狭窄、改善肺功能;临床效果好。Objective To discuss the curative effect of bronchialveolar lavage with ambroxol in the treatment of bronchial tuberculosis. Methods 65 patients with bronchial tuberculosis were randomly divided into two groups.The experiment group was treated with 3HRZE /9HR plan and bronchialveolar lavage with ambroxol and levofloxacin twice a week. The control group was treated with 3HRZE /9HR plan and bronchialveolar lavage with levofloxacin twice a week. Results 1 month after the treatment,the remission rate of tubercular toxic symptom was 90. 9% and71. 9% respectively in the experiment group and in the control group（ P〈0. 05）. 3 months after the treatment,the smear negative rate was 87. 9% and 65. 6% respectively in the experiment group and in the control group（ P〈0. 05）,the curative rate of atelectasis was 84. 8% and 62. 5%（ P〈0. 05）,and the improve rate of lung function was 87. 9% and 65. 6%（ P〈0. 05）. Conclusion Bronchialveolar lavage with ambroxol is an ancillary measure in the treatment of bronchial tuberculosis,which has good curative effect and high safety.

关 键 词：盐酸氨溴索注射液 支气管灌洗术 支气管结核 疗效 

分 类 号：R523[医药卫生—内科学]