移植物血管病的免疫学机制  

Immunological pathogenesis of allograft vasculopathy

作　　者：辛世杰[1] 

机构地区：[1]中国医科大学第一附属医院血管/甲状腺外科,辽宁沈阳110001

出　　处：《遵义医学院学报》2014年第4期353-356,共4页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81170295)

摘　　要：移植物血管病(allograft vasculopathy,AV)是限制移植器官长期存活的重要原因,其特征为移植血管弥散性、向心性狭窄,最终致使移植物缺血并功能衰竭。AV既不是一个完全意义上的自身免疫病,亦不属于纯粹的心血管疾病,免疫损伤是其主要机制;细胞免疫和体液免疫均参与其中,细胞因子和趋化因子亦在AV中发挥作用。本文旨在综述移植物血管病的免疫学机制。Allograft vasculopathy （AV） is the most important long - term limitation to solid - organ transplanta- tion, which is characterized by diffuse, circumferential stenosis of the entire graft vascular tree, eventually compromising perfusion and resulting in graft ischemia and failure. Although AV is not formally an autoimmune disease, nor does it constitute a major cause of cardiovascular disease on a purely numerical basis, immune injury plays a dominant role in AV pathogenesis; cellular and humoral immune responses both participate in AV, cytokines and chemokines contribute to intimal lesions as well. This review will describe the immunological pathogenesis of allograft vasculopathy.

关 键 词：移植物血管病 移植免疫 发病机制 

分 类 号：R332[医药卫生—人体生理学]