左西替利嗪联合沙利度胺治疗慢性荨麻疹的疗效观察  

Curative effect observation of Levocetirizine Dihydrochloride combined with Thalidomide treating chronic urticaria

作　　者：张淑芳[1] 刘平花[1] 陈海针[1] 

机构地区：[1]广东省东莞市中山大学附属东华医院皮肤性病科,东莞523110

出　　处：《北方药学》2014年第11期37-39,共3页Journal of North Pharmacy

摘　　要：目的:观察分析应用盐酸左西替利嗪联合沙利度胺对于慢性荨麻疹进行治疗的临床疗效,为临床治疗寻求依据。方法:选择我院收治的且经其他方式治疗未取得理想效果的慢性荨麻疹患者作为研究对象并进行分组治疗研究,治疗组均应用左西替利嗪联合沙利度胺进行治疗,对照组均应用盐酸左西替利嗪进行治疗。两组研究对象均进行持续4周的治疗,并于1月后进行随访评价,将具体疗效进行对比分析。结果:治疗组总有效率为72.29%,显著高于对照组的33.82%。组间比较差异具有统计学意义(P<0.05)。两组患者不良反应情况差异不具有显著性(P>0.05)。结论:应用盐酸左西替利嗪联合沙利度胺对慢性荨麻疹进行治疗,具有较好的临床疗效,不良反应率低,患者耐受性好,满意度高,有利于患者尽快康复,具有极大的推广价值。Objective：To observe and analyze the application of Levocetirizine Dihydrochloride combined with Thalidomide for the treatment of patients with chronic urticaria, and to seek evidence for the clinical treatment.Method： Patients with chronic urticaria in our hospital,failed to achieve the desired effect with other treatment, were selected for study and treatment in groups. Levocetirizine Dihydrochloride combined with Thalidomide was applied in the treatment group and Levocetirizine Dihydrochloride was applied in the control group. Two groups were treated for 4 weeks and evaluated after a month. Results： The effective rate of the treatment group was 72.29%, significantly higher than the rate of the control group which was 33.82%. The difference between groups was statistically significant （P〈0.05）. The difference of adverse reactions of the two groups was not statistically significant （P〉0.05）.Conclusion：Clinical efficacy of Levocetirizine Dihydrochloride combined with thalidomide for the treatment of patients with chronic urticaria was better with low adverse reactions, well tolerance of patients, high satisfaction, and soon recovery of patlents.So the method is worth being promoted.

关 键 词：荨麻疹 慢性 左西替利嗪 沙利度胺 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]