蛋白酪氨酸磷酸酶1B及其小分子抑制剂的研究进展  

Recent progress in research on protein tyrosine phosphatase 1B and its inhibitors

作　　者：王欣[1] 许潇[1] 孙瑞[1] 刘畅[1] 彭慧兰[1] 马银柱 

机构地区：[1]辽宁大学药学院,沈阳110036

出　　处：《北方药学》2014年第11期92-94,共3页Journal of North Pharmacy

基　　金：辽宁大学青年科研基金项目2011LDQN20;辽宁大学创新创业训练计划校级项目X201310140064

摘　　要：蛋白酪氨酸磷酸酶1B(PTP-1B)是胰岛素和瘦素信号传导通路的负调节因子。目前,作为糖尿病和肥胖症治疗的新靶点,PTP-1B抑制剂的研究引起了广泛的关注。现从PTP-1B简介、生理功能以及抑制剂的结构性质等方面进行综述。Protein tyrosine phosphatase-1 B （PTP1B） has drawn considerable attention as a target for treating type II diabetes and obesity owing to its special role as a negative regulator in both insulin and leptin signaling. It, however, is a great challenge to discover inhibitors specific to PTP-1B. This article gives an overview of reports on PTP-1B＇s structural characteristics, physiological fuctions and structural properties of PTP-IB inhibitors.

关 键 词：蛋白酪氨酸磷酸酶1B 糖尿病 抑制剂 

分 类 号：R977.15[医药卫生—药品]