微波合成具有手性不对称脲单元的脱氧胆酸分子钳人工受体  

Synthesis of Novel Chiral Cholic Acid-based Molecular Tweezers Containing Unsymmetrically Disubstituted Urea Unit Using Microwave Irradiation

作　　者：朱涛[1] 曾碧涛[1] 周黎军[1] 赵志刚[2] 

机构地区：[1]宜宾职业技术学院,四川宜宾644003 [2]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《化学试剂》2014年第9期791-794,共4页Chemical Reagents

基　　金：四川省宜宾市重点科技基金资助项目(2010SF-027);宜宾职业技术学院科技基金资助项目(ybzysc11-09)

摘　　要：在微波辐射条件下,以脱氧胆酸甲酯为隔离基,通过三光气分别桥连取代间硝基苯胺和手性不对称脲为手臂,以良好的产率合成了6个新型标题化合物,其结构均经1HNMR、IR、MS及元素分析确证。利用紫外可见光光度滴定法初步测试了主体化合物对阴离子和氨基酸甲酯的识别作用。结果表明,主体对阴离子和D型氨基酸甲酯有良好的识别性能。A facile and efficient procedure is developed for the synthesis of new chiral cholic acid molecular tweezer artificial receptors by linking an unsymmetrically disubstituted urea to methyl deoxycholate via a carbonate chain using microwave. The structures of these new receptors were confirmed by 1HNMR,IR, MS spectra and elemental analysis. The binding properties were examined by UV-Vis spectra titration. These molecular tweezers not only recognized anions, but also showed good enantioselectivity for D-amino acid methyl esters.

关 键 词：微波辐射 分子钳 脱氧胆酸 分子识别 

分 类 号：O641.3[理学—物理化学]