红外光谱内标法测定感冒清胶囊中对乙酰氨基酚的含量  

Determination of Acetaminophen in Curing Cold Capsules by Internal Standard Method of FT-IR

作　　者：梁奇峰[1] 刘燕静 丘秋霞[1] 

机构地区：[1]嘉应学院化学系,广东梅州514015

出　　处：《化学试剂》2014年第9期812-814,共3页Chemical Reagents

摘　　要：建立了红外光谱内标法测定感冒清胶囊中对乙酰氨基酚含量的方法。选择铁氰化钾作为内标物,定量添加到对乙酰氨基酚中,在对乙酰氨基酚百分含量为0.13%~1.06%范围内,测得混合物红外光谱中对乙酰氨基酚测量峰（（1 654.9±1）cm-1）和铁氰化钾内标峰（（2 117.2±1）cm-1）的峰高比（y=hi/hs）与两者质量比（x=mi/ms）有良好的线性关系,其线性回归方程为y=1.491 9x＋0.247 7,相关系数r=0.998 0。据此测得感冒清胶囊样品中对乙酰氨基酚的含量为5.50%,相对标准偏差为1.7%,加标回收率为97.1%~102.4%,测定结果与药典规定的紫外分光光度法相近。A novel method for the determination of acetamino- phen in curing cold eapsulesby internal standard method of Fourier Transform Infrared Speetrophotometry （ FT-IR ） has been established. Potassium ferrieyanide was added into aeetaminophen as internal reference and the mixtures were detected by FT-IR. The peak of acetaminophen at （ 1 654.9 ± 1 ） cm^-1 was chosen as quantitative peak and the one of potassium ferrieyanide at （2 117.2 ±1） cm^-1 was chosen as inside mark quantitative peak. The ratio of two peak＇s absorbanee （y = hi/hs） had good linear relationship with their mass ratio （x = mi/m,） when the mass fraction of aeetaminophcn was 0. 13% - 1.06%. The linear regression equation was y = 1. 491 9x ＋0. 247 7 ,and the linear correlation coefficient was 0. 998 0. The contents of aeetaminophen in the samples of curing cold capsules were 5.50% ,the relatively standard deviations was 1.7% ,the recoveries of the method were 97.1% - 102.4% , the results agreed well with those of ultraviolet spectrophotometry.

关 键 词：红外光谱内标法 铁氰化钾 对乙酰氨基酚 感冒清胶囊 

分 类 号：O657.33[理学—分析化学]