基于体表参数的2 h口服葡萄糖耐量试验各时间点血糖分析  

Plasma Glucose Values at Different Time Points During 2 hOGTT

作　　者：任秋霞[1] 胡志锋[2] 

机构地区：[1]淮阴卫生高等职业技术学校,江苏省淮安市223300 [2]淮安市淮阴医院

出　　处：《中国全科医学》2014年第26期3052-3059,共8页Chinese General Practice

摘　　要：目的分析2 h口服葡萄糖耐量试验(OGTT)各时间点血糖值及其与年龄、体质指数、腰围、腰臀比、腰高比的关系。方法采用简单随机抽样法选取2013年3月淮安地区某乡镇年龄>45岁人群229例,其中男50例,女179例。根据体质指数将受试者分为:正常体质量组(体质指数<24 kg/m2)和超重与肥胖组(体质指数≥24kg/m2),比较两组2 hOGTT各时间点血糖值;不同性别根据腰围值分为:腰围>参考值(男性≤85 cm,女性≤80 cm)组和腰围≤参考值组,比较不同性别两组2 hOGTT各时间点血糖值;不同性别根据腰臀比分为:腰臀比>参考值(男性≤0.9,女性≤0.85)组和腰臀比≤参考值组,比较不同性别两组2 hOGTT各时间点血糖值;根据腰高比将受试者分为:腰高比≤参考值(参考值为0.5)组和腰高比>参考值组,比较两组2 hOGTT各时间点血糖值。采用直线回归分析年龄、体质指数、腰围值、腰臀比、腰高比与2 hOGTT各时间点血糖值的相关性。结果以2 hOGTT各时间点血糖值为应变量,年龄为自变量进行直线回归分析显示,OGTT后0.5 h、1.0 h和2.0 h时血糖值与年龄均存在直线回归关系(P<0.05)。超重与肥胖组OGTT后0.5 h、1.0 h时血糖值高于正常体质量组(P<0.05);以2 hOGTT各时间点血糖值为应变量、体质指数为自变量进行直线回归分析显示,OGTT后0.5 h和1.0 h时血糖值与体质指数存在直线回归关系(P<0.05)。男性腰围>参考值组OGTT后1.0 h和2.0 h血糖值高于腰围≤参考值组(P<0.05);女性两组2 hOGTT各时间点血糖值比较,差异均无统计学意义(P>0.05);以2 hOGTT各时间点血糖值为应变量,腰围为自变量进行直线回归分析显示,OGTT后0.5 h和1.0 h血糖值与腰围存在直线回归关系(P<0.05)。男性腰臀比>参考值组与腰臀比≤参考值组2 hOGTT各时间点血糖值比较,差异均无统计学意义(P>0.05);女性腰臀比>参考值组OGTT后0.5 h和1.0 h血糖值高于腰臀比≤参考值组(P<0.05);以2 Objective To analyze the plasma glucose values at varying time points of 2 h oral glucose tolerance test（ OGTT） and its relationship to age,body mass index（ BMI）,waist circumference（ WC）,waist-hip ratio（ WHpR）,waist- height ratio（ WHtR）. Methods In March 2013,in Huaian District,by simple random sampling method,a survey was carried out in 229 subjects（ 50 males,179 females,age 〉 45 years old）. According to BMI,the subjects were divided into groups normal BMI（ NBMI group,BMI 〈 24 kg /m2）,overweight and obesity（ OO group,BMI≥24 kg/m2）; the glucose values at varying time points of 2 hOGTT were compared between 2 groups. According to WC,the subjects were divided into groups waist 〉 reference value（ WC of males≤85 cm,WC of females≤80 cm）,waist≤reference value,and the glucose values at varying time points of 2 hOGTT were compared between 2 groups. According to WHpR,the subjects were divided into groups WHR 〉 reference value（ WHpR of males ≤0. 9,WHpR of females ≤0. 85）,WHpR ≤reference value,the glucose values at varying time points of 2 hOGTT were compared between 2 groups. According to WHtR,the subjects were divided into groups WHtR ≤reference value（ reference value = 0. 5）,waist- height ratio 〉 reference value,the glucose values at varying time points of 2 hOGTT were compared between 2 groups. Linear regression correlation was used to analyze the relationship of age,BMI,WC,WHpR,WHtR to glucose values at varying time point of 2 hOGTT. Results Taking glucose values at time points of 2 hOGTT as dependent variable and age as independent variable,linear regression analysis showed that glucose values at hours0. 5,1. 0,2. 0 after OGTT were correlated linearly with age（ P 〈 0. 05）. Glucose values were higher in OO group than in NBMI group at hours 0. 5,1. 0（ P 〈 0. 05）. Taking glucose values at time points of 2 hOGTT as dependent variable and BMI as independent variable,linear regression analysis showed that glucose values were correlated linearl

关 键 词：血糖 口服葡萄糖耐量试验 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]